http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-339783-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5922cbe7c65a9136f85906fa09e7c967 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C- |
| filingDate | 1967-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1968-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-339783-A1 |
| titleOfInvention | PROCEDURE FOR THE INTRODUCTION OF A DOUBLE DELTA LINK IN A 2-METHYL-3-KETO-5ALPHA-STEROID. |
| abstract | Procedure for the introduction of a δ 1 double bond in a 2-methyl-3-keto-5alpha-steroid of the androstane and pregnane series, which comprises the operations of: (1) reacting 2-methyl-3-keto-5alpha-steroid with a hydrocarbon carboxylic acid anhydride of less than 12 carbon atoms in an inert organic solvent and in the presence of a catalytic amount of a strong acid catalyst, to obtain an intermediate 2-methyl-3-acyloxy - δ 2-ene-5alpha-steroid; (2) halogenating the intermediate thus formed with a chlorinating, bromating or iodinating agent in an inert organic solvent, to obtain a corresponding 2-halo-2-methyl-3-keto-5alpha-steroid; y (3) dehydrohalogenar the 2-halo-2-methyl-3-keto-5alpha-steroid with an alkaline or alkaline earth metal carbonate or bicarbonate, alone or in combination with an alkaline, alkaline earth metal chloride, bromide or iodide ammonium, in an inert organic solvent and miscible with water, at a temperature below 50º c, to obtain a corresponding 2-methyl-3-keto- δ 1-ene-5alpha-steroid of the androstane or pregnane series. (Machine-translation by Google Translate, not legally binding) |
| priorityDate | 1967-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 18.