http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-338102-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4acae202b6a15394281949545e70d2f6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-44 |
| filingDate | 1967-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1968-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-338102-A1 |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF NEW CHLOROQUINOLEINS. |
| abstract | Novel 4 - [21 (bis - hydroxymethyl - methoxycarbonyl) - phenylamino] - 7 - and - 8- chloro-quinolines of the formula wherein the chlorine atom is in the 7- or 8- position of the quinoline nucleus, and therapeutioally compatible addition salts thereof with organic or inorganic acids are prepared by transesterification of 4-(21-methoxycarbonyl-phenylamino)-7- or 8-chloroquinoline with a 5- hydroxy-1,3-dioxan derivative of the formula wherein R is a lower alkyl group containing 1 to 6 carbon atoms or an aryl group, followed by acid hydrolysis of the resulting cyclic ketal and optional conversion to a therapeutically compatible addition salt of the product by the action of an organic or inorganic acid. Pharmaceutical compositions having analgesic and anti-inflammatory activity contain as active ingredient 4 - [21 - (bis - hydroxymethylmethoxycarbonyl) - phenylamino] - 7 - or 8- chloro-quinoline or a therapeutically compatible addition salt thereof with an organic or inorganic acid, in association with a pharmaceutical carrier or excipient. |
| priorityDate | 1966-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 19.