http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-336517-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d1a6faffc381ea8994c77336c1d3c9a0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01D9-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-26 |
| filingDate | 1967-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1968-01-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-336517-A1 |
| titleOfInvention | IMPROVEMENTS IN THE PROCEDURE TO OBTAIN A COMPLEX OF A TETRACICLINE ANTIBIOTIC. |
| abstract | An improvement in the process for obtaining a complex of a tetracycline antibiotic from an aqueous medium containing a fermentationproduced tetracycline antibiotic obtained from a filtered and decalcified fermentation broth, by reacting at least a molar equivalent amount of a quaternary ammonium salt therewith at a pH of from 5 to 12, is characterized in that the quaternary ammonium salt has the formula: wherein R is alkyl having 9 to 18 carbon atoms and X is chloride, bromide or iodide. The preferred pH range is 8 to 11 and the antibiotic quaternary ammonium complex is separated as a precipitate or extracted with a waterimmiscible polar organic solvent. The antibiotic as free base or salt is recovered from the organic solvent solution by conventional methods. Typical quaternary ammonium salts are trimethyl 2-methyl decylammonium chloride, trimethyl 2-methylhexadecylammonium chloride and especially Arquad L-11 (mainly C 10-13 alkyl) and Arquad L-15 (mainly C 14 to C 19 alkyl) trimethyl 2-methyl alkyl ammonium chlorides. The tetracycline-antibiotic may be tetracycline, oxytetracycline, chlortetracycline or 7-chloro-6-demethyl tetracycline. Specification 775,916 is referred to. |
| priorityDate | 1966-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 37.