http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-336148-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b6fc801b5bfe5304ffa40d938db6e09 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-74 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-79 |
| filingDate | 1967-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1968-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-336148-A1 |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF NEW AMIDES OF ALIPHATIC CARBOXYL ACIDS. |
| abstract | Novel amides of Formula I in which R 1 -CO- is the acyl radical of an alkanoic, alkenoic or alkapolyene acid having 6 to 14 carbon atoms, R 2 is halogen, C 1-4 alkyl, C 1-6 alkoxy, C 1-4 alkylthio, C 1-4 alkenyloxy, C 1-4 alkanoylamino or C 1-5 (alkoxycarbonyl) and R 3 is hydrogen or C 1-4 alkyl, and their acid addition salts, are prepared by reacting an acid of formula R 1 -COOH, or a reactive functional derivative thereof, with a compound of Formula II or a reactive functional derivative thereof, and, if desired, adding bromine to an alkenoic or alkapolyene acid amide obtained, purifying the addition product by crystallization or another usual process and then debrominating, and/or, if desired, converting a compound obtained of Formula I into an acid addition salt. In a modification of this process, a saturated bromine addition compound of an alkenoic or alkapolyene acid having 6 to 14 carbon atoms, or a reactive functional derivative thereof, is reacted with a compound II and the product is debrominated in known manner. The compounds I in which R 2 is C 1-4 alkanoylamino, can also be prepared by alkanoylation of the corresponding free amino compounds. p-Nitrophenyl 10-undecanoate is prepared by reacting p-nitrophenol with 10-undecenoic acid. N - (5 - amino - 2 - pyridyl) - 10 - undecenamide is prepared by reacting 2-amino-5-nitropyridine with 10-undecenoyl chloride, reducing the resulting N-(5-nitro-2-pyridyl)-10-undecenamide. Pharmaceutical compositions having antiviral and tumour inhibiting properties, for oral, parenteral, rectal or topical administration, comprise a compound I, or an acid addition salt thereof, together with a carrier. |
| priorityDate | 1966-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.