http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-335082-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b6fc801b5bfe5304ffa40d938db6e09 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-233 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-42 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-233 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-42 |
| filingDate | 1966-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1968-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-335082-A1 |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF NEW TETRAHIDROQUINOLEINE DERIVATIVES. |
| abstract | Novel compounds of formula <FORM:1120700/C2/1> and acid addition salts thereof, wherein R1 is low alkyl or alkenyl, R2 is low alkyl or alkenyl or a saturated cycloaliphatic hydrocarbon radical containing up to 9 carbon atoms, R3 is H or low alkyl and R4 is H, halogen, CF3, NO2, low alkyl or alkoxy (in the case of R1, R2 and R3 low indicates groups containing up to 5 carbon atoms and in case of R4 up to 4 carbon atoms), are prepared either by reduction of a compound of formula <FORM:1120700/C2/2> wherein X with Y or with Z represents an additional bond, Y if not included in the additional bond is H, Z if not included in the additional bond is C1- 4 alkyl and R is R2 (imines of the above formula may be prepared in situ from a primary amine and the corresponding 4-keto dihydro quinoline), or by reduction of a compound of formula <FORM:1120700/C2/3> wherein R11, R21 and R31 are R1, R2 or R3 with the exception that one may be alkanoyl or alkoxycarbonyl and/or R11 and/or R21 may b alkenoyl and/or R21 may be cycloalkylcarbonyl, or by alkylation, or alkenylation where appropriate, of a compound where one of R1, R2 or R3 is H. Enamines of the second general formula above are prepared by reduction of the corresponding 4-tertiary-amino-carbostyrils. 1,2-Di-hydroquinolin-4(1H)-ones are prepared by hydrolysis of the above enamines. N-Acyl compounds of the last general formula above are prepared by acylation of the corresponding compound wherein one of R11, R21 or R31 is H. Pharmaceutical compositions, having psycho-stimulant, anti-tussive and anorexic action, in conventional forms for oral, rectal or parenteral administration, comprise an above novel compound and a suitable inert carrier. |
| priorityDate | 1965-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 19.