http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-327925-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_09f406a53dcbc2d191289b00dccb6a85 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D489-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D489-12 |
| filingDate | 1966-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1967-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-327925-A1 |
| titleOfInvention | A PROCEDURE FOR THE PRODUCTION OF HYDROGEN DERIVATIVES OF THEBAINE AND ORIPAVIN. |
| abstract | A process for the production of hydrogenated derivatives of thebaine and oripavine which are compounds of the formula: ** (See formula) ** where R represents a hydrogen atom, a methyl group, the group CnH2n + 1Co-, where n is an integer from 1 to 3 inclusive, benzoyl or nicotinyl; R1 represents a hydrogen atom, an alkyl, alkenyl or alkynyl group containing up to 8 carbon atoms, or an alicyclicly substituted methyl group in which the total number of carbon atoms is from 4 to 8; R 2 represents a hydrogen atom, an alkyl or alkenyl group containing up to 3 carbon atoms, an aryl group or a substituted aryl group; R3 represents a hydrogen atom, an alicyclic group containing from 4 to 8 carbon atoms, an alkyl, alkenyl or alkynyl group containing up to 8 carbon atoms, which may be substituted on carbon atoms numbers 1 to 4 (the carbon atoms # 1 are adjacent to the carbon atom bearing the alcoholic hydroxyl group) by an alicyclic, aryl, alkoxy, aryloxy or hetercyclic group containing oxygen provided that when R represents a hydrogen atom, R3 and R4 do not contain the -CH-aryl and -CH-C = C- systems attached directly to the carbon atom bearing the alcoholic hydroxyl group; whose process consists in hydrogenating, in the presence of a hydrogenation catalyst, (a) a compound of the formula: ** (See formula) ** where R1, R2 and R3 have the meaning given above, or (b) a compound of formula: ** (See formula) ** wherein R1 and R2 have the meaning given above, and reacting the hydrogenated product with an organometallic derivative, such as a Grignard reagent or an organolytic compound, in which the R3 group is attached to a metal atom, or (c) a compound of formula: ** (See formula) ** where ALK represents an alkyl radical, and reducing the hydrogenated product with lithium aluminum hydride to give a product in which R2 and R3 both represent a hydrogen atom and, at will, replace the radicals R and R1 with others of the same group , after stages (a), (b) or (c). (Machine-translation by Google Translate, not legally binding) |
| priorityDate | 1965-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 24.