http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-327492-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_be33e99fadb935f5d8dcfbe27511d8de |
| filingDate | 1966-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1967-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-327492-A1 |
| titleOfInvention | A PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF THEBAINE. |
| abstract | A process for the preparation of new thebaine derivatives of the formula: ** (See formula) ** where Y represents an ethene group (-CH-CH-) or an ethane group (-CH2-CH2-); R1 represents a hydrogen atom, an alkyl, alkenyl or alkynyl group containing up to 8 carbon atoms or an alicyclicly substituted methyl group containing from 4 to 6 carbon atoms; Y R 2 represents an alicyclic group of 5 to 7 carbon atoms, an alkyl group of 1 to 12 carbon atoms, an alkenyl or alkynyl group containing up to 8 carbon atoms in which case the alkyl, alkenyl and alkynyl groups may be substituted one of its carbon atoms by an alicyclic radical, a heterocyclic radical containing oxygen, a heterocyclic radical containing nitrogen, an amino group or a substituted amino group in which latter case the substituting is generally an aliphatic, aromatic or heterocyclic secondary amine or tertiary, provided that when R1 is a methyl group, R2 is neither methyl nor ethyl; wherein the thebaine is reacted with an acrylic acid ester of formula CH2 = CH - COOR2 to give a compound of formula a) at will, the radical R2 is replaced by another radical of the same group by hydrolysis to a compound of formula (I), in which R2 represents hydrogen, which is then esterified with an alcohol of the formula R2OH or converted into the corresponding chloride of acid which is subsequently treated with an alcohol of formula R2OH. b) at will, the radical R1 is replaced by another radical of the same group by converting the compound of formula (I) to a compound of the same formula in which R1 represents a hydrogen atom, which is reacted with an alkyl halide of formula R'X in which X represents a halogen atom, or by converting the compound of formula (II) to a compound of formula ** (See formula) ** with methyl or ethyl azodicarboxylate and reacting this compound with a compound of formula R'Z wherein Z represents a halogen or the radical of an aromatic sulfonic acid, and c) at will, hydrogenated the product or one of the intermediate products obtained during the synthesis. (Machine-translation by Google Translate, not legally binding) |
| priorityDate | 1965-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.