http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-316881-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_29261089dd6ad4bc7a88ce5ced3f4c02 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12 |
| filingDate | 1965-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1965-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-316881-A1 |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF MEDICINES BASED ON MITOCHONDRIA. |
| abstract | Procedure for the preparation of mitochondria-based drugs, consisting of the preparation of lyophilized cardiac mitochondria, proceeding as follows: the heart is extracted from an animal such as a horse, beef, ox or other, previously dead, and to which the fat is removed, the thick vessels and aponeuroses that are joined to it; it is then cut into pieces, frozen, finely ground with the help of a cell crusher in which the cell walls are destroyed; To the obtained puree mixture a solution of sucrose with a concentration of (see formula) of PO4HK2 at a concentration of 0.01 m. in quantity equal to four or five times the volume of this species of puree obtained; the pH is adjusted to a value between 7.2 and 7.4, then centrifuged at low temperature and low speed, to eliminate the cells, nuclei and membranes; what remains supernatant is centrifuged at high speed (10,000 G) and low temperature, which drags the deposit of mitochondria; what is supernatant is removed, the mitochondria are washed and lyophilized. (Machine-translation by Google Translate, not legally binding) |
| priorityDate | 1964-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 15.