http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-314209-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bba842fc4d37dfcaced1b55bc0c91c7c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K15-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K15-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C65-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K15-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F2-38 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C65-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K15-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K15-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F2-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K15-12 |
| filingDate | 1965-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1966-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-314209-A1 |
| titleOfInvention | PROCEDURE FOR OBTAINING DERIVATIVES OF 4H-BENZO (4, 5), CYCLOHEPTA (1, 2-B) THIOPHENE |
| abstract | Novel 4H - benzo - [4,5] - cyclohepta-[1,2-b]thiophene derivatives of general formula <FORM:1102685/C2/1> wherein Z is -CH=CH- or -CH2-CH2-, X is an oxygen atom, or an >NH, >CHOH, >N-CnH2n+1, or >NCmH2mOH radical, in which n signifies 1, 2 or 3, and m is 2 or 3, and acid addition salts thereof, and a compound as above in which X is carbonyl, are prepared by splitting off the elements of water from a 4 - hydroxy - 4H - benzo - [4,5] - cyclohepta[1,2-b]-thiophene derivative of formula <FORM:1102685/C2/2> wherein Z is as defined above, and X1 is an oxygen atom, or >N-CnH2n+1, or a ketalized carbonyl radical, while any ketalized carbonyl radical present is simultaneously deketalized, and when required, reacting with an organic or inorganic acid. A compound of the first formula above in which X is >CHOH, is produced by reduction of a 4-oxo-piperidinopropyline derivative obtained as above, with a complex metal hydride in an inert solvent. Compounds of the first formula above in which X represents >NH are prepared by treating a compound in which X is >N-CnH2n+1, and n is 1, as prepared above, with a chloroformic acid lower alkyl ester, and splitting off the carbalkoxy radical from the resulting 3-(4-carbalkoxy-piperazinyl) propylidene derivative by boiling with potassium hydroxide in n-butane. The product may then be converted to a compound of the first formula above where X is >N-CmH2mOH, by reaction with ethylene oxide, propylene oxide, or chloropropanol. Compounds of the second general formula above are obtained by hydrolysing the reaction product of a compound of formula <FORM:1102685/C2/3> in which Z is as defined above, with a Grignard compound of formula <FORM:1102685/C2/4> in which X1 is as defined above, and Hal signifies a chlorine, bromine or iodine atom. Pharmaceutical compositions having sedative and neuroleptic properties, and which may be administered orally, enterally, or parenterally, in the form of tablets, dragees, or injectable solutions, contain a compound of the first general formula above as the active ingredient. |
| priorityDate | 1964-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.