http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2924983-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c1432597c4e83d4ec79685539afb3f1d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-9493 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-94 |
| filingDate | 2007-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b062ee6d74577b8871b253a97fc1028e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e3b7a9a546c8075a8ac86dfc03c63d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9bb59a551a81a67b798b900861559f9e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8db81a0499c27429cc219349c04e1a1 |
| publicationDate | 2022-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2924983-T3 |
| titleOfInvention | Methods for the detection of immunosuppressive drugs |
| abstract | Methods and reagents are described for improving the bioavailability of a hydrophobic drug, and, in some embodiments, for determining a hydrophobic drug, in a sample suspected of containing a hydrophobic drug. A combination is formed in a medium where the combination comprises the sample, a hemolytic agent where a determination of the hydrophobic drug is performed, and a bioavailability agent for the hydrophobic drug. The bioavailability agent comprises an ionic detergent comprising a chain of at least 10 carbon atoms or a non-ionic detergent comprising a chain of at least 15 repeating units of ethylene oxide or propylene oxide units or a combination of units of ethylene oxide and propylene oxide units. The concentration of the bioavailability agent in the medium is sufficient to enhance the bioavailability of the hydrophobic drug. The medium is incubated under conditions to enhance bioavailability of the hydrophobic drug, and in a determination of hydrophobic drug under conditions to hemolyze the sample cells. For the determination of the hydrophobic drug, reagents are added to the medium to determine the presence and/or amount of the hydrophobic drug in the sample. The reagents comprise at least one antibody to the hydrophobic drug. The medium is examined for the presence of a complex comprising the hydrophobic drug and the antibody to the hydrophobic drug. The presence and/or amount of the complex indicates the presence and/or amount of the hydrophobic drug in the sample. (Automatic translation with Google Translate, without legal value) |
| priorityDate | 2007-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 324.