| abstract |
The present invention relates to n-(phenyl)-2-(phenyl)pyrimidine-4-carboxamide derivatives and related compounds of formula I as HPK1 (hematopoietic progenitor kinase) inhibitors for treating cancer, e.g. Ex. Breast cancer, colorectal cancer, lung cancer, ovarian cancer and pancreatic cancer. Preferred compounds are e.g. N-(5-fluoro-2-(2-(pyridine-2-yl)pyrrolidine-l-yl)phenyl)-2-(2-fluoro-6-methoxyphenyl)pyrimidine-4-carboxamide and N-(5- (5- Fluoro-2- (hexahydropyrrolo [3, 4-b] pyrrol-l (2H) -yl) phenyl) -2- (2-fluoro-6-methoxyphenyl) pyrimidine-4-carboxamide (Automatic translation with Google Translate, without legal value) |