abstract |
Provided are pharmaceutical formulations comprising a recombinant acid α-glucosidase, wherein the recombinant acid Α-glucosidase is expressed in Chinese hamster ovary (CHO) cells and comprises a higher content of n-glucan units bearing a or two manneis-6-phosphate residues compared to a content of N-glycan units bearing one or two mannose-6-phosphate residues of Alglucosidase ALFA; at least one buffer selected from the group consisting of a citrate, a phosphate, and combinations thereof; and at least one excipient selected from the group consisting of mannitol, polysorbate 80, and combinations thereof, wherein the formulation has a pH of from about 5.0 to about 7.0. Methods of treating Pompe disease using these pharmaceutical formulations are also provided. (Automatic translation with Google Translate, without legal value) |