| abstract |
The present invention relates to pyrazine compounds useful as ATR protein kinase inhibitors. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods for using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and comparative evaluation of new kinase inhibitors. The compounds of this invention have the formula I: wherein the variables are as defined herein. (Automatic translation with Google Translate, without legal value) |