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filingDate 2016-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2022-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_82536dbc7b3a9452bebadbf41ec4a697
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publicationDate 2022-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-2920887-T3
titleOfInvention A method to alter the functional state of mRNA that allows its selective and specific recognition
abstract The invention relates to the method for altering the functional state of any mRNA allowing its selective and specific recognition and subsequent selective manipulation. The invention describes a universal principle for increasing the specificity and selectivity of molecular target recognition at the nucleic acid level. The principle of specific and selective recognition of nucleic acids is based on the simultaneous recognition of two or more sequences of the target nucleic acid, while they have to be spaced apart from each other by a certain defined distance. Such a method of nucleic acid recognition through the specific recognition of well-defined nucleic acid sequences that are spaced apart by a defined distance minimizes the probability of stable binding of the interfering construct to inadvertent nucleic acids, thus dramatically increasing the selectivity of the selectivity of Recognition of the target nucleic acid. Specific recognition of defined sequences of a nucleic acid located at a defined distance from each other is achieved by simultaneous complementary interference of short sequence-specific oligonucleotides that are mutually interconnected by the size-specific polymeric linkage moiety. (Automatic translation with Google Translate, without legal value)
priorityDate 2015-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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