| abstract |
The present disclosure provides compounds of formula (i), (ii) and (iii). The provided compounds can bind to protein kinases (eg, Sik) and may be useful for modulating (eg, inhibiting) the activity of a protein kinase (eg, Sik, (eg, Sik1, Sik2, or Sik3)). in a subject or cell. The provided compounds may be useful for treating or preventing a disease (eg, proliferative disease, musculoskeletal disease, genetic disease, hematologic disease, neurological disease, pain condition, psychiatric disorder, or metabolic disorder) in a subject in need. Pharmaceutical compositions, kits, methods, and uses that include or involve a compound described herein are also provided. (Automatic translation with Google Translate, without legal value) |