| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0597f9c318d2aeca86db94711c516383 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-02 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0018
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-575
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-005 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 |
| filingDate |
2006-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2022-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_accaa8032ffcac8261544018eba65702
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ffb8203fb046b835ba36ed34c8aa2dd0 |
| publicationDate |
2022-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
ES-2913277-T3 |
| titleOfInvention |
Enhanced Glycoprotein Production Using Manganese |
| abstract |
A method of producing an erythropoiesis composition comprising sialylated erythropoiesis-stimulating glycoproteins, comprising the steps of: culturing a manganese-responsive host cell producing an erythropoiesis-stimulating glycoprotein in a culture medium containing an effective amount of manganese to increasing sialylation of said erythropoietic composition produced by said manganese-sensitive host cell, wherein the concentration of manganese in said culture medium ranges from 0.4 to 40 µM, and wherein the erythropoiesis-stimulating glycoprotein is erythropoietin, darbepoetin or functional analogues thereof, and wherein the manganese-responsive host cell is a mammalian cell. |
| priorityDate |
2005-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |