http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2912284-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_61f88efcda59d7062a4252ecf6886f58 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate | 2011-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d19dbeac4fe6b7992ecdc4d8c58f443 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_845292f89e21ac861777698badd2fe7e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8993f8f95daed67a7bf870c7cee7105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_050cb96c0f95ff547b54575cf227f4a3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b800b41f7028f666f92c983d6dcdbe88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7bca014e40b18799737d3f7579d9470 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39a126aab32a59bf3ce71eca88153b14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7f69e383a2ca011193b14e21069ef3b |
| publicationDate | 2022-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2912284-T3 |
| titleOfInvention | Substituted pyrazolopyrimidines as activators of glucocerebrosidase |
| abstract | Pharmaceutical composition comprising a compound of the formula **(See formula)** or a pharmaceutically acceptable salt thereof together with a pharmaceutically acceptable carrier, in which R1 is (pyrimidinyl) C0-C4 alkyl, (C3-C7 cycloalkyl )C0-C4 alkyl, (pyrazolyl)C0-C2 alkyl, (pyrrolyl)C0-C2 alkyl, (imidazolyl)C0-C2 alkyl, (thienyl)C0-C2 alkyl, (oxazolyl)C0- C2, (thiazolyl)C0-C2 alkyl, pyrolidinyl, naphthyl, quinolinyl, isoquinolinyl, tetrahydronaphthyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl, tetrahydrofuranyl, morpholinyl, piperidinyl, or thiomorpholinyl, each of which is unsubstituted or substituted with one or more independently selected substituents from halogen, hydroxyl, cyano, nitro, amino, -CHO, -COOH, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkanoyl, mono- or di-C1-C6 alkylamino, mono- or di-C1-C6 alkyl-carboxamide, C1-C6 alkyl ester, C1-C6 alkylthio, C1-C6 alkylsulfonyl, haloalk C1-C2-yl, and C1-C2-haloalkoxy, and with 0 or 1 substituents selected from Y-Z-, where Z is a covalent bond, C1-C4 alkylene, -S-, -O-, -NR -, -C(O)-, -NHC(O)-, or -C(O)NH-, wherein R is hydrogen or C1-C4 alkyl, and Y is phenyl or pyridyl, each of which is unsubstituted or substituted with 1 to 3 substituents independently selected from halogen, hydroxyl, cyano, nitro, amino, C1-C4 alkyl, and C1-C4 alkoxy; R2 is hydrogen or methyl; R3 and R6 are both hydrogen; and R5 and R7 are both methyl; or one of R5 and R7 is methyl and the other is phenyl; or one of R5 and R7 is methyl and the other is difluoromethyl; provided that: R1 is not unsubstituted cyclohexyl when R5 and R7 are both methyl or one of R5 and R7 is methyl and the other is phenyl; R1 is not 1-(4-fluorobenzyl)-1H-pyrazol-4-yl when one of R5 and R7 is methyl and the other is phenyl. |
| priorityDate | 2010-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.