http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2908984-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42e94091a4fc81b8d0237117707cc7ee |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6889 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-522 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6841 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-522 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-04 |
| filingDate | 2018-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89b8fea71f9f474816dd8b5108ddd930 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_217e452998bf896c2fd13666155dd345 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c998a2b3e44f4d526e56c851bf175146 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bcf32243d894cc9f247dc052b45a7ce7 |
| publicationDate | 2022-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2908984-T3 |
| titleOfInvention | 6-amino-7,9-dihydro-8H-purin-8-one derivatives as immunostimulatory agonists of toll-like receptor 7 (TLR7) |
| abstract | A compound having a structure according to Formula (I) **(See Formula)** wherein R1 is (C1-C5 alkyl)O, (C1-C2 alkyl)O(CH2)2-3O, ( C1-C5 alkyl)C(=O)O, (C1-C5 alkyl)NH, (C1-C2 alkyl)O(CH2)2-3NH or (C1-C5 alkyl)C(=O)NH; R2 is, independently of each occurrence, H, C1-C3 alkyl, halo, O(C1-C3 alkyl), CN, or NO2; R3 is H, Me or (CH2)xR4, where the subscript x is 2, 3 or 4; and R4 is H, halo, OH, CN, NH2, NH(C1-C5 alkyl), N(C1-C5 alkyl)2, NH(C3-C6 cycloalkyl), NH(C4-C8 bicycloalkyl), NH(C6- C10 spirocycloalkyl), N(C3-C6 cycloalkyl)2, NH(CH2)1-3(aryl), N((CH2)1-3(aryl))2, a cyclic amine moiety having the structure **(See formula)** a 6-membered aromatic or heteroaromatic moiety or a 5-membered heteroaromatic moiety; wherein an alkyl, cycloalkyl, bicycloalkyl, spirocycloalkyl, cyclic amine, 6-membered aromatic or heteroaromatic or 5-membered heteroaromatic moiety is optionally substituted with one or more substituents selected from OH, halo, CN, (C1-C3 alkyl), O (C1-C3 alkyl), C(=O)(Me), SO2(C1-C3 alkyl), C(=O)(Et), NH2, NH(Me), N(Me)2, NH(Et) , N(Et)2 and N(C1-C3 alkyl)2; and a cycloalkyl, bicycloalkyl, spiroalkyl, or cyclic amine moiety may have a CH2 group replaced by O, S, NH, N(C1-C3 alkyl), or N(Boc). |
| priorityDate | 2017-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 37.