http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2907629-T3
Outgoing Links
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|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_baee372c55802742f9582e25c15ff11a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7125 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65616 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65583 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6561 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6558 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713 |
| filingDate | 2016-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae98450b0132da1f21cc75baa1be967d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e539399f1665d8f9c73322975abda44e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a2f42d5416076abe27f310f65742c53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75ab413a2540c986dc6cec692b807695 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3c1b5cdf03f87e5cf3f68115430bd5f |
| publicationDate | 2022-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2907629-T3 |
| titleOfInvention | A method for preparing a substantially diastereomerically pure phosphorodiamidate oligomer, a phosphorodiamidate oligomer prepared by said method and a pharmaceutical composition comprising said phosphorodiamidate oligomer |
| abstract | A method for preparing a diastereomerically pure substantially phosphorodiamidate morpholino oligomer comprising chiral phosphorous bonds, comprising: selecting substantially stereochemically pure phosphoramidochloridate morpholino monomers; and synthesizing a diastereomerically pure substantially pure phosphorodiamidate morpholino oligomer by stereospecific coupling of selected stereochemically substantially pure phosphoramidochloridate morpholino monomers, wherein said stereospecific coupling is performed in an aprotic solvent, in the presence of a non-nucleophilic tertiary amine or aromatic base , at a temperature of 20 °C to 50 °C; wherein substantially stereochemically pure phosphoramidochloridate morpholino monomers are obtained by separating a diastereoisomeric mixture of phosphoramidochloridate morpholino monomers into substantially stereochemically pure phosphoramidochloridate monomers, and wherein substantially stereochemically pure indicates enantiomers or diastereomers that are in enantiomeric or diastereomeric excess , respectively, equal to or greater than 87%, and "substantially diastereomerically pure" indicates diastereoisomers that are in diastereomeric excess equal to or greater than 87%. |
| priorityDate | 2015-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID414021769 http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID23280244 |
Total number of triples: 31.