| abstract |
A compound that is a benzimidazole of formula (I): **(See formula)** where: R1 is -(CH2)m-R7, **(See formula)** R2 is H, halo, -(CH2 )m-NH2, -(CH2)n-C(=NH)-NH2 or -(CH2)n-NH-(CH2)m-NHR9; R3 is H, F or Cl; each of R4, R5 and R6 is independently H or F; R7 is C1-C6 alkyl, CF3, -SO2R11, -NH-(CH2)2-(NH)r-R8, -NH-CH(R8R9) or a group of the following formula (A): **(See formula )** W is -(CH2)m-, -CH2-O-CH2-, -CH2-S-CH2-, -(CH2)r-S(O)2-CH2- or -(CH2)r-NR8-CH2 -; m is an integer from 1 to 3; n is 1 or 2; p is 1 and V is CH or p is 0 and V is N; q is 0 or 1; r is 0 or 1; R8 is H, -SO2R11, -SO2CF3, -COR11, -C(O)OR11, -CON(R9)2, or -(CH2)nSO2R11; R9 is H or C1-C6 alkyl, each R9 being the same or different when two are present; R10 is -SO2R11, -SO2CF3, -COR11, -CON(R9)2 or -(CH2)nSO2R11 and R11 is C1-C6 alkyl or a pharmaceutically acceptable salt thereof. |