http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2902409-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fe1f35f7f34e45a49c0af551dfabb493 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-433 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 |
| filingDate | 2017-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef20a6168931e79c4fef22286186262f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3272559813a01abc970b0577d301af4d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb3a4f01ed3c3ef7574d6aaa8b990a53 |
| publicationDate | 2022-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2902409-T3 |
| titleOfInvention | Compounds to modulate aquaporins |
| abstract | A compound according to formula (I), wherein formula I is: **(See formula)** or pharmaceutically acceptable salts and stereoisomers thereof, wherein Q is S, -CH2- or O; E is a 5-membered heteroaryl or a 6-membered heteroaryl where E is selected from **(See formula)** where R represents the points of attachment to the rest of the molecule; A1 and A2 are independently selected from the group consisting of CH, CR2, and N; R2 is selected from the group consisting of H, F, Cl, C1-C6 alkyl, C1-C3 alkylene-C3-C6 cycloalkyl, C3-C6 cycloalkyl, and C1-C6 alkyloxy; R5 is selected from the group consisting of H, F, Cl, C1-C6 alkyl, C1-C3 alkylene-C3-C6 cycloalkyl, C3-C6 cycloalkyl, and C1-C6 alkyloxy; R6 is selected from the group consisting of H, F, Cl, C1-C6 alkyl, C1-C3 alkylene-C3-C6 cycloalkyl, C3-C6 cycloalkyl, and C1-C6 alkyloxy; R7 is selected from the group consisting of H, halogen, CF3, CN, OH, C1-C6 alkyl, C3-C6 cycloalkyloxy, C3-C6 cycloalkyl, C1-C6 alkyloxy, O(CH2)mO(CH2)nCH3, O(CH2)mN(R4a)(R4b), C(O)N(R4a)(R4b), SR4a, S(O)2N(R4a)(R4b), S(O2)(R4a), S(O) (NR4a)(R4b), O(CH2)n-heterocycloalkyl, OSO2CH3, and halogenated alkyls or alkoxy; m is an integer selected from the group consisting of 1, 2 and 3; n is an integer selected from the group consisting of 0, 1 and 2; R4a and R4b are independently selected from H, C1-C6 alkyl, and C3-C6 cycloalkyl; R10 is selected from the group consisting of C1-C6 alkyl, C1-C6 alkylene-aryl, C1-C6 alkylene-OR12a, C1-C6 alkylene-N(R12a)(R12b), C1-C6 alkylene-C(O) N(R12a)(R12b), C1-C6 alkylene-C(O)OR12a, C1-C3 alkylene-C3-C6 cycloalkyl, C1-C3 alkylene-C3-C6 heterocycloalkyl, C3-C5 cycloalkyl, aryl or heteroaryl optionally substituted with at least one group selected from the group consisting of halogen, CF3, CN, OH, C1-C6 alkyl, C1-C3 alkylene-C3-C6 cycloalkyl, C3-C6 cycloalkyl, and C1-C6 alkyloxy; R11 is selected from the group consisting of C1-C6 alkyl, C1-C6 alkylene-aryl, C3-C6 cycloalkyl, C1-C3 alkylene-C3-C6 heterocycloalkyl, C1-C6 alkylene-OR12a, aryl or heteroaryl optionally substituted with al least one group selected from the group consisting of halogen, CF3, CN, OH, C1-C6 alkyl, C1-C3 alkylene-C3-C6 cycloalkyl, C3-C6 cycloalkyl, and C1-C6 alkyloxy, R12a and R12b are independently selected from H, C1-C4 alkyl, and cyclopropyl, provided that when Q is S and E is 1,3,4-thiadiazole, then R11 is not aryl or heteroaryl, and provided that the compound is not **( See formula)** |
| priorityDate | 2016-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 195.