| abstract |
A compound of formula (I) **(See formula)** or a salt thereof wherein: R1 is -C1-3 alkyl or cyclopropyl; R2 is H, -CH3, C2-6 alkyl optionally substituted with one, two, three, four or five fluoro, -C2-6alkylOR7, -C2-6alkylNR7R8, -(CH2)mSO2C1-3alkyl, -(CH2) mC(O)NR7R8, -(CH2)mCN, -(CH2)mCO2R7,-(CH2)mNHCO2C(CH3)3 or R2 is -(CH2)nC5-6heteroaryl wherein C5-6heteroaryl is optionally substituted with one or two substituents independently selected from halo, -C1-4alkyl, -C3-4cycloalkyl, and -C0-4alkylOR5; R3 is H, -C1-4alkyl, cyclopropyl, fluoro, chloro, -CH2F, -C0-3alkylOR5, or -C0-3alkylCN; R4 is phenyl or a heteroaryl group each of which is optionally substituted with one, two or three R6 groups which may be the same or different; R5 is H or -C1-3alkyl; each R6 is independently halo, -C1-4alkyl, -C0-3alkylOR7, -C0-3alkylNR9R10, -C0-3alkylCONR9R10, -CN, oxo, -SO2-C1-3alkyl, or -SO2NR9R10; R7 and R8 are each independently selected from -H, -C1-3alkyl and -C2-4alkylO-C0-3alkyl; R9 and R10 are each independently selected from -H and -C1-3alkyl; or R9 and R10 may join together with the nitrogen to which they are attached, to form a 4 to 7 membered heterocyclyl optionally substituted with one or two substituents independently selected from -C1-3 alkyl optionally substituted with up to 3 fluorine atoms, -alkyl C2-4OH, -OH and F; m is an integer selected from 2, 3 or 4; and n is an integer selected from 0, 1, 2, 3 or 4. |