http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2899113-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e009dfd6d673b47824e5db7cda008606 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-551 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 |
| filingDate | 2017-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_873732dc56197bb508910f73f5ed139c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f43641daf6f5bd664c1a22ec9c46d072 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3191f6cc11d2af4fcfe089af14b36996 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77242d3a58ef8db071d5e26164e2a69c |
| publicationDate | 2022-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2899113-T3 |
| titleOfInvention | 2-phenylimidazo[4,5-b]pyridin-7-amine derivatives useful as inhibitors of mammalian ROR1 tyrosine kinase activity |
| abstract | A compound of formula (I') or (I") **(See formula)** or a pharmaceutically acceptable salt thereof, wherein x is an integer from 0 to 4; each Ra is independently selected from C1-alkyl C3, m is 1 or 2, R1 is C1-C6 alkyl, C3-C6 cycloalkyl, C3-C6 cycloalkyl-C1-C6 alkyl, C1-C6 alkyl-C3-C6 cycloalkyl, C1-C6 alkoxy-C1-C6 alkyl, cyano-C1-C6 alkyl or a moiety of formula (II) **(See formula)** Ring A is 5- or 6-membered phenyl or heteroaryl, g is an integer from 0 to 3, each R1a is independently selected from C1-C6 alkyl, R1bO and R1cR1dN, each R1b is independently selected from H and C1-C6 alkyl, each R1c is independently selected from H and C1-C6 alkyl, each R1d is independently selected from H and C1-C6 alkyl, or two R1a, attached to adjacent ring atoms A form, together with the atoms to which they are attached, a 5- or 6-membered ring optionally containing one or more heteroatoms R2 is Cl or Br p is a number in womb from 0 to 3; each R3 is independently selected from C1-C6 alkyl; y is an integer from 0 to 3; Rb is selected from halogen, C1-C3 alkyl and C1-C3 alkoxy; Z is N or CH; W is >Q-R4, -O- or -N(R5)C(O)-; Q is N or CH; n is 1 or 2 when W is >Q-R4 or -O-; n is 0 or 1 when W is -N(R5)C(O)-; R4 is C1-C6 alkyl, R4a[O(CH2)q]r-Y, R4bS(O)2, R4cC(O), cyano-C1-C6 alkyl or a moiety of formula (III) **(See formula)** each q is independently selected from 1,2, 3 and 4; r is 1 or 2; h is an integer from 0 to 3; Y is a direct bond or C(O); L is a direct bond, C1-C4 alkylene or -L1-L2-; L1 is a direct bond or C1-C4 alkylene; L2 is C(O) or NH; R4a is H or C1-C6 alkyl; R4b is C1-C6 alkyl; R4c is C1-C6 alkyl; R4d is C1-C6 alkyl; ring B is selected from phenyl and 5- or 6-membered heteroaryl; R5 is H, C1-C6 alkyl, R5a[O(CH2)u]v or a moiety of formula (IV) **(See formula)** R5a is H or C1-C6 alkyl; each u is independently selected from 1, 2, 3 and 4; v is 1 or 2; M is a direct bond or C1-C4 alkylene; ring C is selected from phenyl and 5- or 6-membered heteroaryl; R5b is C1-C6 alkyl and j is an integer from 0 to 3. |
| priorityDate | 2016-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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