| abstract |
A compound of formula (II): **(See formula)** where X is -(CR6R7)n- or -(CR6R7)m-O-, -(CR6R7)m-S(O)2-; Ar is an aromatic ring system; R1 is -CO2H or a carboxylic acid bioisostere; R2 is hydrogen; R3 is -C(O)CH(aryl)(aryl); R4 and R5 are hydrogen; R6 and R7 are hydrogen; R13 is alkyl; each R15 is independently selected from -C1-6alkyl, -OR13, halo, and -CN; m is 2; n is 3; q is 0 or 1 or 2; and the carboxylic acid bioisostere is selected from the group consisting of tetrazole, tetrazolate, -CONH-tetrazole, oxadiazole, -PO3H2, -C(OH)(CF3)2, N-(aryl or heteroaryl)sulfonamides, acylsulfonamides, and -SO3H; or a pharmaceutically acceptable salt thereof. |