| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a33146a292526a4b5bd944c3d3eedd35 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-41
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-567
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-524
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-526
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-515
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-94
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-77
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-732
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39558
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-32 |
| filingDate |
2020-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2022-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f3b69ddebb7259f42531ebd70ef3f37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5bf700bdfd6d125ccc31348848015a26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14c54a5997e6cb89359f4ddc5dbaabaa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_693b6fd8c1c416833ba7e7b5f1d6149a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c16aeab31ea33e6527ed6bef4ba46171
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bfc4efab18f6113be8172fa54cfeec50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3012566c2e7ba9f40b97fe3d1b5ec2ec |
| publicationDate |
2022-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
ES-2896921-T3 |
| titleOfInvention |
Cancer treatment and prevention using HER3 antigen-binding molecules |
| abstract |
An antigen-binding molecule that is capable of binding to HER3 for use in a method of treating or preventing a cancer in a subject, wherein the cancer comprises cells that have an NRG gene fusion mutation that results in a increased expression of a ligand for HER3 and wherein the antigen-binding molecule comprises: (i) a heavy chain variable region (VH) incorporating the following CDRs: HC-CDR1 having the amino acid sequence of SEQ ID NO: 41 HC-CDR2 having the amino acid sequence of SEQ ID NO: 45 HC-CDR3 having the amino acid sequence of SEQ ID NO: 48; and (ii) a light chain variable region (VL) incorporating the following CDRs: LC-CDR1 having the amino acid sequence of SEQ ID NO: 88 LC-CDR2 having the amino acid sequence of SEQ ID NO: 92 LC -CDR3 having the amino acid sequence of SEQ ID NO: 95. |
| priorityDate |
2019-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |