| abstract |
A synthetic polynucleotide wherein uridine is 100% replaced by 1-methyl-pseudouridine, the synthetic polynucleotide comprising a first region of linked nucleosides, said first region encoding a CRISPR-related protein selected from the group consisting of CRISPR-related proteins CRISPR having any of the amino acid sequence SEQ ID NO 61, 7, 8, 9, 62, 63, 64 or 65 or encoded by any of the nucleic acid sequence SEQ ID NO 1-6, or 110-112. |