http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2896400-T3
Outgoing Links
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|---|---|
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| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate | 2015-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d4d8138548c9aa141aecdac7f2c9a4c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c345b26e41d54d10c023588d8366bdf0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92146f9cd1f19e48e45918afc6109afe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38c2cad5017253167d9f45cfb5014015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ec7881e5159140d877cd940fad54d17 |
| publicationDate | 2022-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2896400-T3 |
| titleOfInvention | Active compounds against bromdomains |
| abstract | A compound having the general formula (XI): **(See formula)** wherein R2a is hydrogen or methyl; R3a is hydrogen or methyl; R7 is hydrogen; R4, R5, R6 and R8b are independently selected from the group consisting of hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, C3-5 cycloalkyl, -CN, -OH, -CF3 and -OCF3; X3 and X4 are independently selected from the group consisting of N and C; when X4 is N, R9b is absent, when X4 is C, R9b is selected from the group consisting of hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, C3-5 cycloalkyl, -CN, -OH, -CF3 and -OCF3; when X3 is N, R10b is absent, when X3 is C, R10b is selected from the group consisting of hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, C3-5 cycloalkyl, -CN, -OH, -CF3 and -OCF3; R11b is selected from the group consisting of hydrogen, halogen, unsubstituted or substituted C1-6 alkyl, unsubstituted or substituted C1-6 alkenyl, unsubstituted or substituted C1-6 alkynyl, unsubstituted or substituted C1-6 alkoxy, -OH , -CN, -NO2, unsubstituted or substituted C3-8 cycloalkyl, unsubstituted or substituted C3-8 cycloalkenyl, unsubstituted or substituted C2-9 heteroalicyclyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, -NR12R13, - NR14C(=O)R15, -NR16C(=O)NR17R18, -NR28C(=O)OR19, -C(=O)R20, -C(=O)OR21, -OC(=O)R21, -C( =O)NR22R23, -S(=O)R24, -SO2R25, -SO2NR26R27 and -OR31; R12, R13, R16, R17, R18, R22, R23, R26 and R27 independently of one another are absent or selected from hydrogen, unsubstituted or substituted C1-6 alkyl, unsubstituted or substituted C1-6 alkenyl, C1-6 alkynyl unsubstituted or substituted, unsubstituted or substituted C1-6 alkoxy, unsubstituted or substituted C3-8 cycloalkyl, unsubstituted or substituted C3-8 cycloalkenyl, unsubstituted or substituted C2-9 heteroalicyclyl, unsubstituted or substituted aryl, unsubstituted heteroaryl or substituted, or R12 and R13, R16 and R17, R17 and R18, R22 and R23, and R26 and R27, taken together with the nitrogen atom to which they are attached, form a ring selected from the group consisting of C2-9 heteroalicyclyl unsubstituted or substituted and unsubstituted or substituted heteroaryl; R14, R15, R19, R20, R21, R24, R25, R28 and R31 independently of one another are absent or selected from hydrogen, unsubstituted or substituted C1-6 alkyl, unsubstituted or substituted C1-6 alkenyl, C1-6 alkynyl unsubstituted or substituted, unsubstituted or substituted C1-6 alkoxy, unsubstituted or substituted C3-8 cycloalkyl, unsubstituted or substituted C3-8 cycloalkenyl, unsubstituted or substituted C2-9 heteroalicyclyl, unsubstituted or substituted aryl, unsubstituted heteroaryl or substituted; A is N; Rx and Ry are independently selected from hydrogen, unsubstituted or substituted C1-6 alkyl, unsubstituted or substituted C1-6 alkenyl, substituted or unsubstituted C1-6 alkoxy, unsubstituted or substituted C3-8 cycloalkyl, C3- 8 unsubstituted or substituted, unsubstituted or substituted C2-9 heteroalicyclyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, -C(=O)R20 and -SO2R25; or Rx and Ry are both considered together with A to form a ring system selected from the group consisting of unsubstituted or substituted C2-9 heteroalicyclyl and unsubstituted or substituted heteroaryl; or one of Rx or Ry is taken together with A to form a ring system selected from the group consisting of unsubstituted or substituted C2-9 heteroalicyclyl and unsubstituted or substituted heteroaryl; and provided that Rx and Ry are independently selected from hydrogen, unsubstituted or substituted C1-6 alkyl, unsubstituted or substituted C1-6 alkenyl, unsubstituted or substituted C1-6 alkoxy, unsubstituted or substituted C3-8 cycloalkyl, unsubstituted or substituted C3-8 cycloalkenyl, unsubstituted or substituted C2-9 heteroalicyclyl, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, -C(=O)R20 and -SO2R25, then R11b cannot be hydrogen; whenever one or more heteroatoms is/are present, it/they are selected from O, N and S; wherein, when any of C1-6 alkyl, C1-6 alkenyl, C1-6 alkynyl, C1-6 alkoxy, C3-8 cycloalkyl, and C3-8 cycloalkenyl is substituted, the substituent group(s) is(are) one (or more) group(s) individually and independently selected from alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heteroaryl, heteroalicyclyl, aralkyl, heteroaralkyl, (heteroalicyclyl)alkyl, hydroxy, oxo, alkoxy, aryloxy, acyl, ester, O-carboxy, mercapto, alkylthio, arylthio, cyano, halogen, carbonyl, thiocarbonyl, C-amido, N-amido, S-sulfonamido, N-sulfonamido, nitro, silyl, sulfenyl, sulfinyl, sulfonyl, haloalkyl, haloalkoxy, trihalomethanesulfonyl, trihalomethanesulfonamido, and amino, including mono- and disubstituted amino groups, and protected derivatives thereof; wherein, when the C2-9 heteroalicyclyl is substituted, the substituent group(s) is(are) one (or more) group(s) independently selected from the group consisting of alkyl, alkenyl , alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heteroaryl, heteroalicyclyl, aralkyl, heteroaralkyl, (heteroalicyclyl)alkyl, hydroxy, oxo, alkoxy, aryloxy, acyl, ester, O-carboxy, mercapto, alkylthio, arylthio, cyano, halogen, C-amido, N-amido, S-sulfonamido, N-sulfonamido, isocyanate, thiocyanate, isothiocyanate, nitro, silyl, haloalkyl, haloalkoxy, trihalomethanesulfonyl, trihalomethanesulfonamido, and amino, including mono- and disubstituted amino groups, and the protected derivatives thereof themselves, including aromatic ring-forming substituents, including aryl and heteroaryl, when fused with the heteroalicyclyl group; and wherein, when any of the aryl or heteroaryl is substituted, the hydrogen atoms are replaced by substituent group(s) which is(are) one (or more) group(s) independently selected from alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heteroaryl, heteroalicyclyl, aralkyl, heteroaralkyl, (heteroalicyclyl)alkyl, hydroxy, oxo, alkoxy, aryloxy, acyl, ester, O-carboxy, mercapto, alkylthio, arylthio, cyano, halogen , carbonyl, thiocarbonyl, C-amido, N-amido, S-sulfonamido, N-sulfonamido, nitro, silyl, sulfenyl, sulfinyl, sulfonyl, haloalkyl, haloalkoxy, trihalomethanesulfonyl, trihalomethanesulfonamido, and amino, including mono- and disubstituted amino groups, and protected derivatives thereof, including cycloalkyl, cycloalkenyl, cycloalkynyl and heterocyclyl substituents on the aryl or heteroaryl which form a non-aromatic ring when fused to the aryl or heteroaryl. |
| priorityDate | 2014-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 1650.