| abstract |
A pharmaceutical composition comprising a compound of formula (III): **(See formula)** or an enantiomer, a diastereomer, a stereoisomer, a pharmaceutically acceptable salt thereof, wherein R2 is independently selected from CH3 and CD3 R13 is independently selected from H, and C1-4 alkyl R3 is independently selected from H and C1-4 alkyl; R4 is independently selected from C1-6 alkyl substituted with 1-3 R9, -(CR7R7)r-C3-6 cycloalkyl substituted with 1-3 R8, and -(CR7R7)r-aryl substituted with 1-3 R8; R5 is independently selected from H, F, Cl, CN and C1-4alkyl; provided that one of R5 is H; R6 is **(See Formula)** R7 is independently selected from H, C1-4 alkyl, and C3-6 cycloalkyl; or R7 and R7, together with the carbon atom to which they are both attached, form a C3-6 cycloalkyl ring; R8 is independently selected from H, C1-6 alkyl substituted with 1-5 R9, C3-6 cycloalkyl, F, Cl, Br, CN, =O and COOH; R9 is independently selected from H, F, Cl, NH2, OH, OC1-5 alkyl, C1-5 alkyl, C3-6 cycloalkyl, and phenyl, wherein when R9 is Cl, NH2, or OH, it is unsubstituted on the C1 of the alkyl. to which it is attached; R10 is independently selected from H, D, C1-4 alkyl and F; R11 is independently selected from CN, -C(=O)R12 and tetrazolyl; R12 is independently selected from OH, OC1-4alkyl, NH2, and NHSO2C1-4alkyl and r is independently selected from zero, 1, 2, 3, and 4; and a pharmaceutically acceptable carrier or diluent. |