http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2895155-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bc2b03342511abc88f60c63f2acd96d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fc97d5c88a9eaabc8299985ec2fcc1b3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-14 |
| filingDate | 2016-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3607f62b06d7aabdb04a92f6bfe909d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7eeb5e62514906ceed7a978004468115 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d4b9013ce460bf3fa843282cb718ba36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99f2d2e132dbf1ec52635a8af7b90568 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e116e362b3fa77187ba5e55d6563759c |
| publicationDate | 2022-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2895155-T3 |
| titleOfInvention | Saxitoxins modified in 11,13 for the treatment of pain |
| abstract | A compound of formula (I): **(See formula)** where R1 is H, OH, -OS(O)3-, -OS(O)2R5, -OC(O)R6, -NR7C(O) R7a, -OC(O)NR10R10a, -NR11R11a, -NH3+, -NR13S(O)2R13a, or -NR14C(O)NR14aR14b; X1 is R3 and X2 is R9; or X1 and X2 together with the -NC(O)- to which they are attached form a 5 or 6 membered ring where X1, X2 and one or two additional ring atoms are independently selected from -C(O)-, -O -, -S-, -NR8- and -C(R4)(R4a)- provided that only one of -O-, -S- and -NR8- is selected; and wherein the 5- or 6-membered ring is optionally fused at two adjacent carbon atoms, or is optionally fused at a carbon atom and a nitrogen atom that are adjacent to each other, to form a 6-saturated or unsaturated bicyclic ring. 12 members; where the additional 1, 2, 3, 4, 5 or 6 bicyclic ring atoms are independently -CR12= or -C(R12)2-; or X1 and X2 together with the -NC(O)- to which they are attached form 1,3-dioxo-hexahydro-1H-4,7-methaneisoindolyl; each R4 and R4a is independently H; C1-6 alkyl; or when the 6-12 membered ring fuses to a -C(R4)(R4a)- , one or both of R4 and R4a in the -C(R4)(R4a)- form a single or double bond with an atom of adjacent ring; R8 is hydrogen; C1-6 alkyl; phenyl optionally substituted with 1, 2 or 3 groups independently selected from halo, C1-6 alkyl, halo-C1-6 alkyl, hydroxy, C1-6 alkoxy, halo-C1-6 alkoxy, nitro and cyano; or when the 6-12 membered ring is fused to -NR8-, R8 forms a single bond with an adjacent ring atom; each R12 is independently hydrogen, halo, C1-6 alkyl, halo-C1-6 alkyl, or aryl; R3 is -C(O)C1-6alkyl, -C(O)OC1-6alkyl or -C(O)phenyl where phenyl is optionally substituted with one or two groups independently selected from halo, C1-6alkyl, halo -C1-6 alkyl, C1-6 alkoxy and aryl; R5 is H, C1-6 alkyl or aryl optionally substituted with 1, 2, 3 or 4 R5a; each R5a, when present, is independently halo, C1-6 alkyl, halo-C1-6 alkyl, hydroxy, C1-6 alkoxy, halo-C1-6 alkoxy, C1-6 alkylthio, halo-C1-6 alkylthio, alkylsulfinyl C1-6, halo-C1-6 alkylsulfinyl, C1-6 alkylsulfonyl, halo-C1-6 alkylsulfonyl, nitro, amino, C1-6 alkylamino, di-C1-6 alkylamino, phenyl or cyano; R9 is C1-6 alkyl, C1-6 alkoxy or phenyl where phenyl is optionally substituted with one or two groups independently selected from halo, C1-6 alkyl, halo-C1-6 alkyl, C1-6 alkoxy and aryl; R6 is C1-6 alkyl; aryl optionally substituted with 1, 2, 3 or 4 R6a; aralkyl where aryl is optionally substituted with 1, 2, 3 or 4 R6a; heteroaryl optionally substituted with 1, 2, 3 or 4 R6a; heterocyclic optionally substituted with 1, 2, 3 or 4 R6a; biphenyl optionally substituted on any ring with 1, 2 or 3 R6a; or cycloalkyl optionally substituted with 1, 2, 3 or 4 groups independently selected from C1-6 alkyl and halo-C1-6 alkyl; each R6a, when present, is independently halo, C1-6 alkyl, halo-C1-6 alkyl, hydroxy, C1-6 alkoxy, halo-C1-6 alkoxy, nitro, C1-6 alkylthio, halo-C1-6 alkylthio , C1-6 alkylsulfinyl, halo-C1-6 alkylsulfinyl, C1-6 alkylsulfonyl, halo-C1-6 alkylsulfonyl, amino, C1-6 alkylamino, di-C1-6 alkylamino, phenyl or cyano; R7 is hydrogen or C1-6 alkyl; R7a is C1-6 alkyl; aryl optionally substituted with 1, 2, 3 or 4 R7b; aralkyl where aryl is optionally substituted with 1, 2, 3 or 4 R7b; heteroaryl optionally substituted with 1, 2, 3 or 4 R7b; heterocyclic optionally substituted with 1, 2, 3 or 4 R7b; biphenyl optionally substituted on any ring with 1, 2 or 3 R7b; or cycloalkyl optionally substituted with 1, 2, 3 or 4 groups independently selected from C1-6 alkyl and halo-C1-6 alkyl; each R7b, when present, is independently halo, C1-6 alkyl, halo-C1-6 alkyl, hydroxy, C1-6 alkoxy, halo-C1-6 alkoxy, nitro, C1-6 alkylthio, halo-C1-6 alkylthio , C1-6 alkylsulfinyl, halo-C1-6 alkylsulfinyl, C1-6 alkylsulfonyl, halo-C1-6 alkylsulfonyl, amino, C1-6 alkylamino, di-C1-6 alkylamino, phenyl or cyano; R10 is hydrogen or C1-6 alkyl; R10a is C1-6 alkyl; aryl optionally substituted with 1, 2, 3 or 4 R10b; aralkyl where aryl is optionally substituted with 1, 2, 3 or 4 R10b; phenylcarbonyl where phenyl is optionally substituted with 1, 2 or 3 R10b; heteroaryl optionally substituted with 1, 2, 3 or 4 R10b; heterocyclic optionally substituted with 1, 2, 3 or 4 R10b; biphenyl optionally substituted on any ring with 1, 2, 3 or 4 R10b; or cycloalkyl optionally substituted with 1, 2, 3 or 4 groups independently selected from C1-6 alkyl and halo-C1-6 alkyl; each R10b, when present, is independently halo, C1-6 alkyl, halo-C1-6 alkyl, hydroxy, C1-6 alkoxy, halo-C1-6 alkoxy, nitro, C1-6 alkylthio, halo-C1-6 alkylthio , C1-6 alkylsulfinyl, halo-C1-6 alkylsulfinyl, C1-6 alkylsulfonyl, halo-C1-6 alkylsulfonyl, amino, C1-6 alkylamino, di-C1-6 alkylamino, phenyl or cyano; R11 is hydrogen or C1-6 alkyl; R11a is C1-6 alkyl; aryl optionally substituted with 1, 2, 3 or 4 R11b; aralkyl where aryl is optionally substituted with 1, 2, 3 or 4 R11b; heteroaryl optionally substituted with 1, 2, 3 or 4 R11b; heterocyclic optionally substituted with 1, 2, 3 or 4 R11b; biphenyl optionally substituted on any ring with 1, 2, 3 or 4 R11b; or cycloalkyl optionally substituted with 1, 2 or 3 groups independently selected from C1-6 alkyl and halo-C1-6 alkyl; and each R11b, when present, is independently halo, C1-6 alkyl, halo-C1-6 alkyl, hydroxy, C1-6 alkoxy, halo-C1-6 alkoxy, nitro, C1-6 alkylthio, halo-C1-6 alkylthio 6, C1-6 alkylsulfinyl, halo-C1-6 alkylsulfinyl, C1-6 alkylsulfonyl, halo-C1-6 alkylsulfonyl, amino, C1-6 alkylamino, di-C1-6 alkylamino, phenyl or cyano; R13 is hydrogen or C1-6 alkyl; R13a is C1-6 alkyl; aryl optionally substituted with 1, 2, 3 or 4 R13b; aralkyl where aryl is optionally substituted with 1, 2, 3 or 4 R13b; heteroaryl optionally substituted with 1, 2, 3 or 4 R13b; heterocyclic optionally substituted with 1, 2, 3 or 4 R13b; biphenyl optionally substituted on any ring with 1, 2, 3 or 4 R13b; or cycloalkyl optionally substituted with 1, 2, 3 or 4 groups independently selected from C1-6 alkyl and halo-C1-6 alkyl; each R13b, when present, is independently halo, C1-6 alkyl, halo-C1-6 alkyl, hydroxy, C1-6 alkoxy, halo-C1-6 alkoxy, C1-6 alkylthio, halo-C1-6 alkylthio, alkylsulfinyl C1-6, halo-C1-6 alkylsulfinyl, C1-6 alkylsulfonyl, halo-C1-6 alkylsulfonyl, nitro, amino, C1-6 alkylamino, di-C1-6 alkylamino, phenyl or cyano; R14 is hydrogen or C1-6 alkyl; R14a is hydrogen or C1-6 alkyl; R14b is C1-6 alkyl; aryl optionally substituted with 1, 2, 3 or 4 R14c; aralkyl where aryl is optionally substituted with 1, 2, 3 or 4 R14c; heteroaryl optionally substituted with 1, 2, 3 or 4 R14c; heterocyclic optionally substituted with 1, 2, 3 or 4 R14c; biphenyl optionally substituted on any ring with 1, 2, 3 or 4 R14c; or cycloalkyl optionally substituted with 1, 2, 3 or 4 groups independently selected from C1-6 alkyl and halo-C1-6 alkyl; and each R14c, when present, is independently halo, C1-6 alkyl, halo-C1-6 alkyl, hydroxy, C1-6 alkoxy, halo-C1-6 alkoxy, C1-6 alkylthio, halo-C1-6 alkylthio, C1-6 alkylsulfinyl, halo-C1-6 alkylsulfinyl, C1-6 alkylsulfonyl, halo-C1-6 alkylsulfonyl, nitro, amino, C1-6 alkylamino, di-C1-6 alkylamino, phenyl or cyano; or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, tautomer, or mixture thereof. |
| priorityDate | 2015-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 100.