| abstract |
A vaccine composition comprising: (a) at least one recoverable biocompatible macrocapsule comprising between about 5x105 and about 15x105 immunoisolated allogeneic cells secreting at least 20 ng/24 hours of GM-CSF and (b) an antigenic component, where the at least one biocompatible macrocapsule comprises: a core comprising the allogeneic cells and an internal coil, where the distance between the needles in the internal coil is about 1 mm ± 0.1 mm, and where the allogeneic cells are distributed in the inner coil; and a semi-permeable membrane surrounding the core that allows the diffusion of GM-CSF through it, where said at least one biocompatible macrocapsule has a length from more than 5 mm to 25 mm. |