http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2891825-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2df2e1189fa8605916aa5ef7b6df8f95 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_afd115dec46c157d3739020ebd4d866b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B51-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D9-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-04 |
| filingDate | 2017-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e7f4600f6ebe6e4311069be01cf8053 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4122a98681d44e0e7807bd0c967a6b0e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0b54f674a0d30b5079d3c9ef3368ae3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4890b1e6ec5ab9f6ff480d6be22a296 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4340f1cad7ec0b91323e5c61e7a559c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69dd7a3965ee6717753df4aaf38ff223 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4be836fe62de71dd94d416f381d51c1d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4b879b6061a1f0e920910410584aade http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62d588e19c7b921a00e6e9a8905fa976 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cfb6c7971346f59badfd3b64f3fccba0 |
| publicationDate | 2022-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2891825-T3 |
| titleOfInvention | Method for producing a diphenylmethane derivative |
| abstract | A method of producing a compound of the following formula 1a, the method comprising the steps of: (1) reacting a compound of the following formula 2 with a compound of the following formula 3 and subjecting the resulting product to a cyclization reaction, to obtain a compound of the following formula 4; (2) subjecting the compound of the formula 4 to aldehyde or amidation, followed by reacting the resulting product with a compound of the following formula 5 and performing reduction, to obtain a compound of the following formula 6; and (3) reacting the compound of formula 6 with a compound of the following formula 7, and performing deprotection and reduction, wherein the cyclization reaction is a cyclization reaction using a Vilsmeier reagent, a cyclization reaction using a group leaving, a cyclization reaction using a halide, or a cyclization reaction using a Mitsunobu reaction, **(See formula)** in the formulas, A is oxygen (O) or sulfur (S); n is 1 or 2; PG is a protecting group; X' is halogen or C1-7 alkyl; X, Y, and Hal are each independently halogen; B is (B-1) **(See formula)** or (B-2) **(See formula)** where Ra, Rb, Rc and Rd are each independently hydrogen, halogen, hydroxy, mercapto , cyano, nitro, amino, carboxy, oxo, C1-7 alkyl, C1-7 alkylthio, C2-7 alkenyl, C2-7 alkynyl, C1-7 alkoxy, C1-7 alkoxy-C1 alkyl -7, C2-7 alkenyl-C1-7 alkyloxy, C2-7 alkynyl-C1-7 alkyloxy, C3-10 cycloalkyl, C3-7 cycloalkylthio, C5-10 cycloalkenyl, C3-10 cycloalkyloxy , C3-10 cycloalkyloxy-C1-7 alkoxy, phenyl-C1-7 alkyl, C1-7 alkylthio-phenyl, phenyl-C1-7 alkoxy, mono- or di-C1-7 alkylamino, mono- or di-C1-7 alkylamino-C1-7 alkyl, C1-7 alkanoyl, C1-7 alkanoylamino, C1-7 alkylcarbonyl, C1-7 alkoxycarbonyl, carbamoyl, mono- or di-C1-7 alkylcarbamoyl 7, C1-7 alkylsulfonylamino, phenylsulfonylamino, C1-7 alkylsulfinyl, C6-14 arylsulfanyl, C6-14 arylsulfonyl, C6-14 aryl, 5- to 13-membered heteroaryl, heterocycloal 5 to 10 membered chyl, 5 to 10 membered heterocycloalkyl-C1-7 alkyl, or 5 to 10 membered heterocycloalkyl-C1-7 alkoxy; a ring C is C3-10 cycloalkyl, C5-10 cycloalkenyl, C6-14 aryl, 5 to 13 membered heteroaryl, or 5 to 10 membered heterocycloalkyl; alkyl, alkenyl, alkynyl, and alkoxy are each independently unsubstituted or have one or more substituents selected from the group consisting of halogen, hydroxy, cyano, nitro, amino, mercapto, C1-7 alkyl, and C2-alkynyl. 7; cycloalkyl, cycloalkenyl, aryl, heteroaryl, and heterocycloalkyl are each independently unsubstituted, or have one or more substituents selected from the group consisting of halogen, hydroxy, cyano, nitro, amino, mercapto, C1-4alkyl, and alkoxy. C1-4; and heteroaryl and heterocycloalkyl each independently contain one or more heteroatoms selected from the group consisting of N, S and O. |
| priorityDate | 2016-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 262.