http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2891543-T3
Outgoing Links
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| filingDate | 2010-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5167a5525c87a252a974ff7e463e0212 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f3834778b3522d49faff09b3446c809 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8915d32eca629428401085b042e6b90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2aeeb021223889c15d0ac8a2fd2874e7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79e468384b5f004300606c91f9532a5d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0a2a13e55101233e1a672f27b70ece0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a4872a3add0821465598705b5cd0a04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d7ba420f7f67daf32b3d522fd8157a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24f8ebb8b83798a00690cb75155faf20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59779488765d688574d021c6c4d843a8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74a7aa66fd6c5c3178a4980b1fa80588 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8270552f7392c473fd0d4d34fad6cbb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3d82f4546e0c67fb0d682576998a93a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7572a2286785fa7144fbeff4039f19d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b8d725f343b02264f00cb8996ccc6fd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_423344499fa48983be6e9fcec33f6b3b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e45e76a3ae52233d3a17e53116f6372 |
| publicationDate | 2022-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2891543-T3 |
| titleOfInvention | Bruton's tyrosine kinase inhibitors |
| abstract | A pharmaceutically acceptable salt of a compound having the formula: **(See formula)** where: X1 is -O-, -CR5R6- or -NR7-; X2 is =CR8- or =N-; p is 0-5; y is 0, 1 or 2; z is 0, 1 or 2, where z is 0 or 1 when y is 2, and z is 1 or 2 when y is 0; each R1 is independently halogen, -NO2, -CN, -OR, -SR, -N(R)2, -C(O)R, -CO2R, -C(O)C(O)R, -C(O )CH2C(O)R, -S(O)R, -S(O)2R, -C(O)N(R)2, -SO2N(R)2, -OC(O)R, -N(R )C(O)R, -N(R)N(R)2, -N(R)C(=NR)N(R)2, -C(=NR)N(R)2, -C=NOR , -N(R)C(O)N(R)2, -N(R)SO2N(R)2, -N(R)SO2R, -OC(O)N(R)2, or an optionally substituted group selected from C1-12 aliphatic, phenyl, a 3-7 membered saturated or partially unsaturated monocyclic carbocyclic ring, a 7-10 membered saturated or partially unsaturated bicyclic carbocyclic ring, a 3-7 membered saturated or partially unsaturated monocyclic carbocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen and sulfur, a 7-10 membered saturated or partially unsaturated bicyclic heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen and sulfur, an 8- 10 membered, a 5-6 membered heteroaryl ring having 1-3 sele heteroatoms independently selected from nitrogen, oxygen, and sulfur, or an 8-10 membered bicyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, or: two R1 groups on adjacent carbon atoms are taken together with their atoms intermediates to form an optionally substituted ring selected from phenyl, a 3-7 membered saturated or partially unsaturated monocyclic carbocyclic ring, a 7-10 membered saturated or partially unsaturated bicyclic carbocyclic ring, a 3-membered saturated or partially unsaturated monocyclic heterocyclic ring, 7-membered having 1-2 heteroatoms independently selected from nitrogen, oxygen and sulfur, a 7-10 membered saturated or partially unsaturated bicyclic heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen and sulfur, a bicyclic aryl ring from 8-10 membered, a 5-6 membered heteroaryl ring having 1-3 heteroat omos independently selected from nitrogen, oxygen, and sulfur, or an 8-10 membered bicyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, or: two R1 groups on nonadjacent carbon atoms are taken together with its intermediate atoms to form an optionally substituted bridge of a bridged bicyclic group, wherein the bridge is a C1-3 hydrocarbon chain, wherein a methylene unit is optionally replaced by -NR-, -O-, -C( O)-, -OC(O)-, -C(O)O-, -S-S- or -S-, or: two R1 groups on the same carbon atom are taken together with their intermediate atoms to form a fused ring optionally substituted spiro selected from a 3-7 membered saturated or partially unsaturated carbocyclic ring, or a 3-7 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen and sulfur; each R is independently hydrogen or an optionally substituted group selected from C1-6 aliphatic, phenyl, a 3-7 membered saturated or partially unsaturated carbocyclic ring, a 3-7 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, or a 5-6 membered heteroaryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, or: two R groups on the same nitrogen are taken together with their intermediate atoms to form an optionally substituted 3-7 membered saturated or partially unsaturated heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen and sulfur; each of R2, R3, R5, R6 and R8 is independently R, halogen, -NO2, -CN, -OR, -SR, -N(R)2, -C(O)R, -CO2R, -C( O)C(O)R, -C(O)CH2C(O)R, -S(O)R, -S(O)2R, -C(O)N(R)2, -SO2N(R)2 , -OC(O)R, -N(R)C(O)R, -N(R)N(R)2, -N(R)C(=NR)N(R)2, -C(= NR)N(R)2, -C=NOR, -N(R)C(O)N(R)2, -N(R)SO2N(R)2, -N(R)SO2R or -OC(O )N(R)2; or: R3 and R4 are optionally taken together with their intermediate atoms to form an optionally substituted ring selected from a 3-7 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen and sulfur, or a 7-10 membered saturated or partially unsaturated bicyclic heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen and sulfur; each of R4 and R7 is independently R, -CN, -C(O)R, -CO2R, -C(O)C(O)R, -C(O)CH2C(O)R, -C(O) N(R)2, -S(O)R, -S(O)2R or -S(O)2N(R)2; the A1 ring is: where T is a bivalent C1-5 straight or branched, saturated or unsaturated hydrocarbon chain, where one, two or three methylene units of T are optionally and independently replaced by -C(R)2 -, -NR-, -N(R)C(O)-, -C(O)N(R)-, -N(R)SO2-, -SO2N(R)-, -O-, -C( O)-, -OC(O)-, -C(O)O-, -S-, -SO-, -SO2-, -C(=S)-, -C(=NR)-, -N= N- or -C(=N2)-; ring A2 is an optionally substituted ring selected from phenyl, a 3-7 membered saturated or partially unsaturated monocyclic carbocyclic ring, a 7-10 membered saturated or partially unsaturated bicyclic carbocyclic ring, a 3-membered saturated or partially unsaturated monocyclic heterocyclic ring -7 membered having 1-2 heteroatoms independently selected from nitrogen, oxygen and sulfur, a 7-10 membered saturated or partially unsaturated bicyclic heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen and sulfur, a bicyclic aryl ring 8-10 membered, a 5-6 membered heteroaryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen and sulfur, or an 8-10 membered bicyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen and sulfur; L is a covalent bond or an optionally substituted bivalent saturated or unsaturated C1-7 linear or branched hydrocarbon chain, wherein one, two, or three methylene units of L are independently replaced by -Cy-, -CR2-, -NR-, -N(R)C(O)-, -C(O)N(R)-, -N(R)SO2-, -SO2N(R)-, -O-, -C(O) -, -OC(O)-, -C(O)O-, -S-, -SO-, -SO2-, -C(=S)-, -C(=NR)-, -N=N- or -C(=N2)-, wherein at least one methylene unit of L is replaced by -N(R)-; and each Cy is independently an optionally substituted bivalent ring selected from phenylene, a 3-7 membered saturated or partially unsaturated carbocyclylene, a 3-7 membered saturated or partially unsaturated monocyclic heterocyclylene having 1-2 heteroatoms independently selected from nitrogen, oxygen and sulfur, or a 5-6 membered heteroarylene having 1-3 heteroatoms independently selected from nitrogen, oxygen and sulfur; wherein, furthermore, suitable monovalent substituents on a substitutable carbon atom of an "optionally substituted" group are independently halogen; -(CH2)0-4R°; -(CH2)0-4OR°; -O(CH2)0-4R°, -O-(CH2)0-4C(O)OR°; -(CH2)0-4CH(OR°)2; -(CH2)0-4SR°; -(CH2)0-4Ph, which can be substituted with R°; -(CH2)0-4O(CH2)0-1Ph which can be substituted with R°; -CH=CHPh, which can be substituted with R°; - (CH2)0-4O(CH2)0-1-pyridyl which can be substituted with R°; -NO2; -CN; -N3; -(CH2)0-4N(R°)2; -(CH2)0- 4N(R°)C(O)R°; -N(R°)C(S)R°; -(CH2)0-4N(R°)C(O)NR°2; -N(R°)C(S)NR°2; -(CH2)0-4N(R°)C(O)OR°; -N(R°)N(R°)C(O)R°; -N(R°)N(R°)C(O)NR°2; -N(R°)N(R°)C(O)OR°; -(CH2)0-4C(O)R°; -C(S)R°; -(CH2)0- 4C(O)OR°; -(CH2)0-4C(O)SR°; -(CH2)0-4C(O)OSiR°3; -(CH2)0-4OC(O)R°, -OC(O)(CH2)0-4SR-, SC(S)SR°; -(CH2)0-4SC(O)R°; -(CH2)0-4C(0)NR°2; -C(S)NR°2; -C(S)SR°; -SC(S)SR°, -(CH2)0-4OC(O)NR°2; -C(O)N(OR°)R°; -C(O)C(O)R°; -C(O)CH2C(O)R°; -C(NOR°)R°; -(CH2)0-4SSR°; -(CH2)0-4S(O)2R°; -(CH2)0- 4S(O)2OR°; -(CH2)0-4OS(O)2R°; -S(O)2NR°2; -(CH2)0-4S(O)R°; -N(R°)S(O)2NR°2; -N(R°)S(O)2R°; -N(OR°)R°; -C(NH)NR°2; -P(O)2R°; -P(O)R°2; -OP(O)R°2; -OP(O)(OR°)2; SiR°3; -(C1-4 linear or branched alkylene)O-N(R°)2; or -(C1-4 linear or branched alkylene)C(O)O-N(R°)2, where each R° is independently hydrogen, C1-6 aliphatic, -CH2Ph, -O(CH2)0-1Ph; wherein, furthermore, suitable substituents on a substitutable nitrogen of an "optionally substituted" group include -R†, -NR†2, -C(O)R†, -C(O)OR†, -C(O) C(O)R†, -C(O)CH2C(O)R†, -S(O)2R†, -S(O)2NR†2, -C(S)NR†2, -C(NH) NR†2 or -N(R†)S(O)2R†; wherein each R† is independently hydrogen, C1-6 aliphatic, unsubstituted -OPh, or an unsubstituted saturated, partially unsaturated, 5-6 membered aryl ring having 0-4 heteroatoms independently selected from nitrogen, oxygen and sulfur. |
| priorityDate | 2009-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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