| abstract |
An isolated peptide that reduces leukocyte recruitment selected from (i) an isolated peptide comprising SEQ ID NO: 1, (ii) the isolated peptide of (i), wherein the peptide is modified by pegylation, acetylation, glycosylation , biotinylation, or substitution of one or more L-amino acids with the same type of D-amino acids, and (iii) the isolated peptide of (i), wherein the peptide comprises one or more modified amino acid residues or amino acid analogs , wherein the modified amino acid residues are modified by methylation, amidation, or acetylation, and wherein the amino acid analogs are selected from β-alanine, norvaline, norleucine, 4-aminobutyric acid, ornithine, hydroxyproline, sarcosine, citrulline , cysteic acid, cyclohexylalanine, 2-aminoisobutyric acid, 6-aminohexanoic acid, t-butylglycine, phenylglycine, o-phosphoserine, N-acetylserine, N-formylmethionine, and 3-methylhistidine. |