| abstract |
A method of preparing magnesium saroglitazar of Formula (I), **(See formula)** comprising the method: (a) reacting a hydroxy compound (A) with a mesylate compound (A1) in a mixture of organic solvents in the presence of a base and a phase transfer catalyst at a temperature of 35°C to 85°C to obtain an alkoxy ester compound of Formula (II); **(See formula)** (b) hydrolyzing the alkoxy ester compound of Formula (II) with a base to obtain saroglitazar; and (c) reacting saroglitazar with a magnesium source to obtain saroglitazar magnesium of Formula (I); wherein the organic solvent mixture comprises cyclohexane and one or more of alcohols selected from methanol, ethanol, isopropanol, 2-propanol, 1-butanol, and t-butyl alcohol; ketones selected from acetone, butanone, and methyl isobutyl ketone; esters selected from ethyl acetate, isopropyl acetate, t-butyl acetate, and isobutyl acetate; chlorinated hydrocarbons selected from methylene dichloride, ethylene dichloride, and chlorobenzene; hydrocarbons selected from pentane, hexane and heptane and ethers selected from tetrahydrofuran, 1,4-dioxane, diisopropyl ether, diethyl ether and methyl tert-butyl ether. |