http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2886576-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_457fac7c233bc5cbc81f7bfbc9dc5086 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-001 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16 |
| filingDate | 2015-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81e292ee5835b11037c9dd57248632fb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b477da8e6e9faf86cbebb0691976d29b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c389da58e8792b2a09386ece3eace7e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_266b70455b8b57d77c5fc6062ddb87a5 |
| publicationDate | 2021-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2886576-T3 |
| titleOfInvention | Compound of multiple targets with anticoagulant and antiplatelet activity, preparation method for the same and use thereof |
| abstract | A multitargeted compound with anticoagulation and platelet GPIIb/IIIa receptor antagonism, said compound having a structure as shown in Formula (1): A-L-B-L'-C Formula (1) wherein A and B are sites of thrombin binding, C is a platelet GPIIb/IIIa receptor binding site, L is a first linker and L' is a second linker, wherein L' has a structure as shown in Formula (2): (( Gly)n1-(Ser)n2)n3 Formula (2) wherein n1 is 1, 2, 3 or 4; n2 is 0 or 1; and n3 is 0, 1, 2 or 3; or L' has a structure as shown in Formula (3): (Glu-Ala-Ala-Ala-Lys)n1 Formula (3) where n1 is 0, 1, 2 or 3 or L' has a structure as is shown in Formula (4): (Arg-Val-Leu-Ala-Glu-Ala)n1 Formula (4) where n1 is 0, 1, 2 or 3; where A has a structure as shown in Formula (5): A1-A2-A3-A4 Formula (5) where A1 is D-Phe; A2 is Pro or Pip; A3 is Arg, Lys, Orn or Har; and A4 is Pro, D-Pro or Ser; wherein B has a structure as shown in Formula (6): B1-B2-B3-B4-B5 Formula (6) wherein B1 is a dipeptide consisting of any two acidic amino acids; B2 is Val, Leu, Ile, Nle or Phe; B3 is Hyp, Ser, Pro or an N-methyl amino acid; B4 is a dipeptide consisting of any two acidic amino acids; and B5 is an amino acid selected from the group consisting of Tyr, Trp, Phe, Leu, Nle, Ile, Val, Cha and Pro or B5 is a dipeptide comprising at least one amino acid selected from Tyr, Trp, Phe, Leu, Nle , Ile, Val, Cha and Pro; where C has a structure as shown in Formula (7): Cys-Har-C1-Asp-Trp-Pro-C2 Formula (7) where C1 is Gly or Ser; C2 is Cys or a structure obtained by replacing -OH in Cys with -NH2; and a disulfide bond is formed between two mercapto groups in Formula (7); where L has a structure as shown in Formula (8): L1-L2-L3-L4-Gly-Asp-L5 Formula (8) where L1 is Gly, Ala, Val or Gly-Gly; L2 is Gly or Cys; L3 is Gly, Gly-Gly, Gly-Gly-Gly, or a dextrorotatory amino acid; L4 0 is Asn or Gln; L5 is one selected from Phe, Tyr, a derivative in which a benzene ring of Phe is substituted and a derivative in which a benzene ring of Tyr is substituted. |
| priorityDate | 2015-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 181.