http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2885243-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42e94091a4fc81b8d0237117707cc7ee |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-501 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5355 |
| filingDate | 2018-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c039ad579599d4f1444b59e3959c7a6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d16c4e6a1031f323612101f0ddcb78e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30a4c5c08327ee0ebd8c730a5ffa06fe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d279816f272191b6bd83a2349fd658a1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13f261136b8b8e6474412a603f7bcf4c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d26b35025a7b63af0747adb23feefb4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18b78d61c45f3cf21e28ed84dca66f1c |
| publicationDate | 2021-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2885243-T3 |
| titleOfInvention | Substituted nitrogen-containing compounds |
| abstract | A compound having the structure of Formula (I) **(See formula)** or a salt thereof, wherein: R1 is: each W is independently NR1b or O; Z is a bond or CHR1d; X is independently N or CR1a, where X is N in only 0, 1 or 2 positions; each R1a is independently H, F, Cl, -OH, -CN, C1-3 alkyl, C1-3 fluoroalkyl, C3-6 cycloalkyl, C1-3 alkoxy, or C1-3 fluoroalkoxy; each R1b is independently H, C1-3alkyl, C2-3fluoroalkyl, C3-6cycloalkyl; R1c is independently H, deuterium, C1-4alkyl, C1-4fluoroalkyl, or C3-6cycloalkyl; R1d is H, C1-3 alkyl, C1-4 fluoroalkyl, or C3-6 cycloalkyl; Y is -C(R6)2-, -C(R6)2-C(R6)2-, -C(O)-, -C(O)-C(R6)2-, -C(R6)2 -C(O)- or -SO2-; V is -O-, -NR4-, -CR5R5-, -S-, -S(O)-, -SO2- or -C(O)-; where if V is -O-, -S-, -S(O)-, -SO2-, or -C(O)-, then Y is not -SO2-, and where if V is -O-, - S- or NR4, then Y is not C(R6)2, and where if V is -S(O)-, -SO2-, or C(=O)-, then Y is not -C(=O)- , -C(=O)-C(R6)2-; L1 is -C(R)2-, -C(O)- or -C(R)2-C(R)2-; wherein R is independently H, F, OH, C1-3 alkyl, C1-3 hydroxyalkyl, C1-3 alkoxyalkyl, or C1-3 fluoroalkyl; wherein R is not -OH or F if it is attached to a carbon atom that is adjacent to a nitrogen atom: ring B is phenyl, pyridinyl, pyrimidinyl, pyrrazolyl, thiazolyl, imidazolyl, triazolyl, tetrazolyl, oxadiazolyl, thiadiazolyl, isoxazolyl, isothiazolyl, pyrrolyl, pyrazinyl, oxazolyl, pyridazinyl, pyrrolidinyl, or imidazolidinyl; R2 is a C6-10 aryl or 5 to 10 membered heterocycle ring containing from 1 to 4 heteroatoms selected from N, O and S, the heterocycle ring optionally containing oxo substitution, the aryl or heterocycle rings are substituted with 0- 3 R2a; R2a is independently OH, =O, CN, halo, C1-4 alkyl, C1-4 deuteroalkyl, C1-4 fluoroalkyl, C1-4 alkoxy, C1-4 deuteroalkoxy, C1-4 fluoroalkoxy, C3-6 cycloalkyl, C3-6 cycloalkoxy 6, C(=O)NR4bR4b, C(=O)C1-4alkyl, SO2Re, NR4bSO2R4b or a 4 to 6 membered heterocycle having 1, 2, 3 or 4 heteroatoms selected from O, S and N, containing the heterocycle optionally an oxo substitution and is substituted with 0-3 R2b; R2b is independently C1-3 alkyl, C1-3 fluoroalkyl, C1-3 hydroxyalkyl, C3-6 cycloalkyl, or C3-6 fluorocycloalkyl; R3a is H, halo, OH, CN, C1-3alkyl, C1-3hydroxyalkyl, C1-3fluoroalkyl, C1-3alkoxy, or C3-6cycloalkyl, where if V is -O-, -NR4-, -S -, -S(O)-, -SO2- or -C(=O)-, then R3a is not halo, and where if V is -O-, -NR4-, -S-, then R3a is not OH , CN; R3b is H, =O, C1-3alkyl, C1-3hydroxyalkyl, C1-3fluoroalkyl, C1-3alkoxy, or C3-6cycloalkyl; R4 is H, C1-3alkyl, C2-3fluoroalkyl, C2-3hydroxyalkyl, CO2R4a, C(O)R4a, SO2R4a, C(O)N(R4bR4b), SO2N(R4bR4b), or OH; R4a is C1-3 alkyl, C1-3 fluoroalkyl, C3-6 cycloalkyl, C3-6 fluorocycloalkyl, C6-10 aryl or a 4 to 10 membered heterocycle having 1, 2, 3 or 4 heteroatoms selected from O, S and N, where the aryl or heterocycle is substituted with 0-3 R4c; R4b is independently H, C1-3 alkyl, C2-3 fluoroalkyl, C3-6 cycloalkyl, C3-6 fluorocycloalkyl, C6-10 aryl or a 4 to 10 membered heterocycle having 1, 2, 3 or 4 heteroatoms selected from O , S and N; alternatively, 2 R4b, together with the atom to which they are attached, come together to form a 3 to 6 membered saturated ring containing 0-2 additional heteroatoms selected from O, S and N; R4c is independently H, F, Cl or C1-3 alkyl; R5 is independently H, F, OH, C1-3 alkoxy, C1-3 fluoroalkoxy, C1-3 alkyl, C1-3 fluoroalkyl, C1-3 hydroxyalkyl, C3-6 cycloalkyl, C3-6 fluorocycloalkyl, NR5bR5b, O-R5c or 2 R5 are =O; wherein if one R5 is F, OH or NR5bR5b, then the other R5 is not OH or NR5bR5b. R5b is independently H, C1-3 alkyl, C3-6 cycloalkyl, C(O)Ra, SO2Ra, or C(O)NRbRb; alternatively, 2 R5b, together with the atom to which they are attached, come together to form a 3 to 6 membered saturated ring containing 0-2 heteroatoms selected from O, S, or N; R5c is independently H, C1-3 alkyl, C3-6 cycloalkyl, or C(O)NRbRb; R6 is independently H, OH, F, C1-3 alkyl, C1-3 deuteroalkyl, C1-3 fluoroalkyl, C3-6 cycloalkyl, C3-6 fluorocycloalkyl, C1-3 alkoxy, C1-3 hydroxyalkyl, C1-3 hydroxydeuteroalkyl, alkoxyalkyl C1-3 or C1-3 fluoroalkoxyalkyl or NR6bR6b; wherein if one R6 on a carbon atom is F, OH or NR6bR6b, then the other R6 on the same carbon atom is not OH or NR6bR6b. R6b is independently H, C1-3 alkyl, C3-6 cycloalkyl, C(O)Ra, SO2Ra, or C(O)NRbRb; alternatively, two R6 together with the same atom to which they are attached may form a 3 to 6 membered saturated ring containing 0-2 heteroatoms selected from O, S and N; Ra is independently H, C1-3 alkyl, C2-3 fluoroalkyl, C3-6 cycloalkyl, C3-6 fluorocycloalkyl, C6-10 aryl or a 4 to 10 membered heterocycle having 1, 2, 3 or 4 heteroatoms selected from O , S and N; Rb is independently H, C1-3 alkyl, C2-3 fluoroalkyl, C3-6 cycloalkyl, C3-6 fluorocycloalkyl, C6-10 aryl or a 4 to 10 membered heterocycle having 1, 2, 3 or 4 heteroatoms selected from O , S and N; alternatively, two Rb together with the atom to which they are attached join to form a 3 to 6 membered saturated ring, containing 0-2 heteroatoms selected from O, S and N; each Rd is independently H, F, C1-3 alkyl, C1-3 fluoroalkyl, C1-3 alkoxy, C1-3 fluoroalkoxy, C1-3 hydroxyalkyl, C3-6 cycloalkyl, halo, OH, =O, CN, OCF3, OCHF2 , CHF2CF3 or C(O)NReRe; each Re is independently H, C1-3 alkyl, C2-3 fluoroalkyl, C3-6 cycloalkyl, C2-3 hydroxyalkyl, C2-3 alkoxyalkyl, C6-10 aryl, or a 5- to 10-membered heteroaryl having 1, 2, 3 or 4 heteroatoms selected from O, S and N; alternatively, 2 Re together with the atom to which they are attached, come together to form a 3 to 6 membered saturated ring, containing 0-2 heteroatoms selected from O, S, or N; and n is 0, 1 or 2. |
| priorityDate | 2017-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 1382.