http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2885003-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_51872a5a09cc9a30fcbd1153ee34cdc6 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4985 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4985 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 |
| filingDate | 2017-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0cb014f4943b3ca4b60fb13d67ac35a1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2c7c7499202f8bce5b4e4058707cb31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07dc6a4e668422c101bae10d0b4b3a90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_63db45349b974f8e423520b534795e0d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86b2ef39ea8fe551ee2fa6a2440add95 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6daec6288d5ff3072c5b99bf68373c9f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_656feb54c33a93882fec3524ae9af3d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ddf57c53a7f91c6e4ee9273250a2afd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25c32445146d682634183f2f64b6e9b3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9047a1bd1b9955d99685fc01801fcf7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97434aa3f75647b4e9990270747a7ee7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3eb4deba6486ecbb12f4f9e93057ef4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_252ebd716585f0d563594b4fb846d169 |
| publicationDate | 2021-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2885003-T3 |
| titleOfInvention | Bicyclic fused SGC stimulators |
| abstract | A compound of Formula I, or a pharmaceutically acceptable salt thereof, **(See formula)** in which: the nucleus formed by rings E and A together with substituents (Jc)p is represented by the following formula: **(See formula)** in which the C atom with a symbol * represents the point of attachment to the ring containing G, Z and Q; and the C atom with a ** symbol represents the junction point of the 2 instances of J; W is a ring B which is a phenyl; wherein each J is independently selected from hydrogen and methyl; n is 1; and JB is halogen; each JC is independently selected from hydrogen, halogen, C1-4 aliphatic, C1-4 alkoxy, or -CN; wherein each of said C1-4 aliphatic and C1-4 alkoxy is optionally and independently substituted with up to 3 occurrences of C1-4 alkoxy, C1-4 haloalkoxy, -OH or halogen; Q, G, and Z are each independently N, S, or O, wherein at least two of Q, G, and Z are N; q is 0, 1 or 2; R10 is C1-6 alkyl optionally and independently substituted with 0-3 occurrences of R15, phenyl optionally and independently substituted with 0-3 occurrences of R15, 5- or 6-membered heteroaryl optionally and independently substituted with 0-3 occurrences of R15, Cycloalkyl C3-8 optionally and independently substituted with 0-3 occurrences of R15 or 3-8 membered heterocyclyl optionally and independently substituted with 0-3 occurrences of R15; wherein each of said 5-6 membered heteroaryl ring and each of said 3-8 membered heterocyclyl contains up to 3 ring heteroatoms independently selected from N, O or S; R11 is H, NRa2Rb2, -C(O)NRa2Rb2, -C(O)R15a, -SO2Rb2, -SRb2, halo, -OCF3, -CN, hydroxy, C2-6 alkenyl optionally and independently substituted with 0-2 occurrences of Rb2, C2-6 alkynyl optionally and independently substituted with 0-2 occurrences of Rb2; C1-6 alkyl optionally and independently substituted with 0-5 occurrences of R15, C1-6 alkoxy optionally and independently substituted with 0-5 occurrences of R15, phenyl optionally and independently substituted with 0-3 occurrences of R15, heteroaryl from 5 to 6 members optionally and independently substituted with 0-3 occurrences of R15, C3-8 cycloalkyl optionally and independently substituted with 0-3 occurrences of R15 or 3-8 membered heterocyclyl optionally and independently substituted with 0-3 occurrences of R15; wherein each of said 5-6 membered heteroaryl and each of said 3-8 membered heterocyclyl contains up to 3 ring heteroatoms independently selected from N, O or S; or when R10 is a substituent on Z, R10 and R11, together with Z and the carbon to which R11 is attached, form an optionally independently substituted 3-10 membered heterocyclic ring with 0-3 occurrences of R15; wherein each of said 3-10 membered heterocyclyl contains up to 3 ring heteroatoms independently selected from N, O or S; R15 is halo, -ORb2, -SRb2, -NRa2Rb2, -C(O)Rb2, -C(O)NRa2Rb2, -NRb2C(O)ORb2, -OC(O)NRa2Rb2, C2-4 alkenoxy, C3-8 cycloalkyl optionally and independently substituted with 0-3 occurrences of R18, phenyl optionally and independently substituted with 0-3 occurrences of R18, 5 or 6 membered heteroaryl optionally and independently substituted with 0-3 occurrences of R18 or optional 3-10 membered heterocyclyl and independently substituted with 0-3 occurrences of R18; wherein each of said 5 or 6 membered heteroaryl ring and each of said 3 to 10 membered heterocyclyl contains up to 3 ring heteroatoms independently selected from N, O or S; R15a is C3-8 cycloalkyl optionally and independently substituted with 0-3 occurrences of R18, phenyl optionally and independently substituted with 0-3 occurrences of R18, 5- or 6-membered heteroaryl optionally and independently substituted with 0-3 occurrences of R18, or heterocyclyl 3-10 membered optionally and independently substituted with 0-3 occurrences of R18; wherein each of said 5 or 60 membered heteroaryl ring and each of said 3 to 10 membered heterocyclyl contains up to 3 ring heteroatoms independently selected from N, O or S; each R18 is independently selected from halo, hydroxy, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, or phenyl; Ra2 is hydrogen, -C(O)Rb2, C1-6 alkyl or C1-6 haloalkyl; and Rb2 is hydrogen, C1-6 alkyl or C1-6 haloalkyl. |
| priorityDate | 2016-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 522.