http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2883172-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2de680c086736ed5fbc20971125ef5a3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_61f88efcda59d7062a4252ecf6886f58 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-09 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-455 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C41-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C43-23 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C41-30 |
| filingDate | 2016-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f749d151a0abdf360342a7ea4756e58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1489fe384a90c656c192c437721d02ea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_715a4e0871763492c624c56aacba5a0f |
| publicationDate | 2021-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2883172-T3 |
| titleOfInvention | Process for preparing high purity (Z) -endoxyphene |
| abstract | A process for preparing (Z)-endoxyfen, comprising (i) recrystallizing an input crystalline solid comprising a mixture of (Z)-endoxyfen (1) and (E)-endoxyfen (2) in a first solvent, wherein the first solvent is isopropyl acetate, toluene, methyl ethyl ketone, or methyl isobutyl ketone, to provide a first crystalline solid and a first mother liquor, wherein the first mother liquor has a ratio of (1) to (2) of at least 1, 3 times greater than the proportion in the input crystalline solid; **(See formula)** (ii) recrystallize a solid produced by concentrating the first mother liquor, or by removing the first solvent in the first mother liquor, from a second solvent, wherein the second solvent is methanol, ethanol, or acetone, to give a second crystalline solid and a second mother liquor; (iii) optionally recrystallizing the second crystalline solid from the second solvent an additional one to five times to give a third crystalline solid; wherein the third crystalline solid has a ratio of (Z)-endoxyfen (1) to (E)-endoxyfen (2) greater than 20:1. |
| priorityDate | 2015-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID7148 http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419539811 |
Total number of triples: 27.