http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2881807-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a69dfea389c90cbb13b1985b974800b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-7051 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5156 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5158 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-73 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-569 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-572 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2809 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0636 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70578 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2863 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-5434 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1138 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-5443 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-7158 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6851 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0011 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6813 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-468 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70503 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70521 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-715 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 |
| filingDate | 2016-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d30421f1a9b36ae0cbe12cb8ce30ad09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa6767576de36bb8b7de21b52ebd7521 |
| publicationDate | 2021-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2881807-T3 |
| titleOfInvention | Tumor-specific anti-EGFR antibody and its application |
| abstract | An antibody that specifically recognizes EGFRvIII expressed or EGFR overexpressed by tumor cells, wherein the antibody comprises a light chain variable region and a heavy chain variable region, and the light chain variable region CDR1 has a sequence of amino acids selected from the group consisting of SEQ ID NO: 41, SEQ ID NO: 47, SEQ ID NO: 55; the light chain variable region CDR2 has an amino acid sequence selected from the group consisting of SEQ ID NO: 42, SEQ ID NO: 53; the light chain variable region CDR3 has an amino acid sequence selected from the group consisting of SEQ ID NO: 43, SEQ ID NO: 48, SEQ ID NO: 54, SEQ ID NO: 56, SEQ ID NO: 57; the heavy chain variable region CDR1 has the amino acid sequence of SEQ ID NO: 44; the heavy chain variable region CDR2 has an amino acid sequence selected from the group consisting of SEQ ID NO: 45, SEQ ID NO: 49, SEQ ID NO: 51, SEQ ID NO: 52; the heavy chain variable region CDR3 has an amino acid sequence selected from the group consisting of SEQ ID NO: 46, SEQ ID NO: 50; Preferably, the antibody includes: antibody (a), wherein the light chain variable region thereof has CDR1 of SEQ ID NO: 41, CDR2 of SEQ ID NO: 42, CDR3 of SEQ ID NO: 43, and the heavy chain variable region thereof has CDR1 of SEQ ID NO: 44, CDR2 of SEQ ID NO: 45, CDR3 of SEQ ID NO: 46, antibody (b), wherein the light chain variable region thereof has CDR1 of SEQ ID NO: 47, CDR2 of SEQ ID NO: 42, CDR3 of SEQ ID NO: 48, and the heavy chain variable region thereof has CDR1 of SEQ ID NO: 44, CDR2 of SEQ ID NO: 49, CDR3 of SEQ ID NO: 50, antibody (c), wherein the light chain variable region thereof has CDR1 of SEQ ID NO: 41, CDR2 of SEQ ID NO: 42, CDR3 of SEQ ID NO: 48, and the heavy chain variable region thereof has CDR1 of SEQ ID NO: 44, CDR2 of SEQ ID NO: 51, CDR3 of SEQ ID NO: 50, antibody (d), wherein the heavy chain variable region light chain thereof has CDR1 of SEQ ID NO: 41, CDR2 of SEQ ID NO: 42, CDR3 of SEQ ID NO: 43, and the heavy chain variable region thereof has CDR1 of SEQ ID NO: 44, CDR2 of SEQ ID NO: 52, CDR3 of SEQ ID NO: 50, antibody (e), wherein the light chain variable region thereof has CDR1 of SEQ ID NO: 41, CDR2 of SEQ ID NO: 42, CDR3 of SEQ ID NO: 43, and the heavy chain variable region thereof has CDR1 of SEQ ID NO : 44, CDR2 of SEQ ID NO: 45, CDR3 of SEQ ID NO: 50, antibody (f), wherein the light chain variable region thereof has CDR1 of SEQ ID NO: 41, CDR2 of SEQ ID NO : 53, CDR3 of SEQ ID NO: 54, and the heavy chain variable region thereof has CDR1 of SEQ ID NO: 44, CDR2 of SEQ ID NO: 51, CDR3 of SEQ ID NO: 50, antibody (g) , wherein the light chain variable region has CDR1 of SEQ ID NO: 41, CDR2 of SEQ ID NO: 42, CDR3 of SEQ ID NO: 54, and the heavy chain variable region thereof has CDR1 of SEQ ID NO: 44, CDR2 of SEQ ID NO: 51, CDR3 of SEQ ID NO: 50, 5 antibody (h), in which the region light chain variable region thereof has CDR1 of SEQ ID NO: 55, CDR2 of SEQ ID NO: 42, CDR3 of SEQ ID NO: 56, and the heavy chain variable region thereof has CDR1 of SEQ ID NO: 44 , CDR2 of SEQ ID NO: 45, CDR3 of SEQ ID NO: 50, antibody (i), wherein the light chain variable region thereof has CDR1 of SEQ ID NO: 41, CDR2 of SEQ ID NO: 53 , CDR3 of SEQ ID NO: 56, and the heavy chain variable region thereof has CDR1 of SEQ ID NO: 44, CDR2 of SEQ ID NO: 52, CDR3 of SEQ ID NO: 50, antibody (j), in wherein the light chain variable region thereof has CDR1 of SEQ ID NO: 41, CDR2 of SEQ ID NO: 42, CDR3 of SEQ ID NO: 56, and the heavy chain variable region thereof has CDR1 of SEQ ID NO: 44, CDR2 of SEQ ID NO: 52, CDR3 of SEQ ID NO: 50, or antibody (k), wherein the light chain variable region thereof has CDR1 of SEQ ID NO: 41, CDR2 of SEQ ID NO: 42, CDR3 of SEQ ID NO: 57, and the heavy chain variable region thereof has CDR1 of SEQ ID NO: 44, CDR2 of SEQ ID NO: 52, CDR3 of SEQ ID NO: 50. More preferably, the amino acid sequence of the antibody heavy chain variable region is shown at positions 124 to 239 of SEQ ID NO: 13; and the amino acid sequence of the light chain variable region of the antibody is shown at positions 1-108 of SEQ ID NO: 13; The amino acid sequence of the antibody heavy chain variable region is shown at positions 124 to 239 of SEQ ID NO: 59; and the amino acid sequence of the light chain variable region of the antibody is shown at positions 1-108 of SEQ ID NO: 59; The amino acid sequence of the antibody heavy chain variable region is shown at positions 124 to 239 of SEQ ID NO: 61; and the amino acid sequence of the light chain variable region of the antibody is shown at positions 1-108 of SEQ ID NO: 61; The amino acid sequence of the antibody heavy chain variable region is shown at positions 124 to 239 of SEQ ID NO: 63; and the amino acid sequence of the light chain variable region of the antibody is shown at positions 1-108 of SEQ ID NO: 63; The amino acid sequence of the antibody heavy chain variable region is shown at positions 124 to 239 of SEQ ID NO: 65; and the amino acid sequence of the light chain variable region of the antibody is shown at positions 1-108 of SEQ ID NO: 65; The amino acid sequence of the antibody heavy chain variable region is shown at positions 124 to 239 of SEQ ID NO: 67; and the amino acid sequence of the light chain variable region of the antibody is shown at positions 1-108 of SEQ ID NO: 67; The amino acid sequence of the antibody heavy chain variable region is shown at positions 124 to 239 of SEQ ID NO: 69; and the amino acid sequence of the light chain variable region of the antibody is shown at positions 1-108 of SEQ ID NO: 69; The amino acid sequence of the antibody heavy chain variable region is shown at positions 124 to 239 of SEQ ID NO: 71; and the amino acid sequence of the light chain variable region of the antibody is shown at positions 1-108 of SEQ ID NO: 71; The amino acid sequence of the antibody heavy chain variable region is shown at positions 124 to 239 of SEQ ID NO: 73; and the amino acid sequence of the light chain variable region of the antibody is shown at positions 1-108 of SEQ ID NO: 73; The amino acid sequence of the antibody heavy chain variable region is shown at positions 124 to 239 of SEQ ID NO: 75; and the amino acid sequence of the light chain variable region of the antibody is shown at positions 1-108 of SEQ ID NO: 75; o The amino acid sequence of the antibody heavy chain variable region is shown at positions 124 to 239 of SEQ ID NO: 77; and the amino acid sequence of the light chain variable region of the antibody is shown at positions 1-108 of SEQ ID NO: 77. |
| priorityDate | 2015-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 126.