http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2879351-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2916980b6c918a618cbc9da7ddf3ddda |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-497 |
| filingDate | 2017-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3f2d7b1a321c501e5f2d9cd33803a10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c50688e5b40514c10e1c0919e48efe10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e7863eceabb67eecf4d846cd3a08c96 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d32f45dc38569af35b45ccbb465c4577 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4061c6195c955b54f2ae264c7c472fd5 |
| publicationDate | 2021-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2879351-T3 |
| titleOfInvention | Salts of piperazine derivatives obtained by adding acids |
| abstract | A salt obtained by the addition of hydrochloric acid, maleic acid, tartaric acid, sulfuric acid, or p-toluenesulfonic acid to compounds of formula (I): **(See formula)** where X denotes O or CH2, n denotes 0 or 1, and Q denotes one of the following groups: **(See formula)** Z1 is S, O, NR3; Z2, Z2', Z3 independently denote CR5, CR6 or N; R5, R5', R6, R7 independently denote H, Hal, NR3R4, NO2, or a straight or branched chain alkyl group with 1 to 12 carbon atoms, where 1 to 3 CH2 groups may be substituted by a group selected from: O, NR3, S, SO, SO2, CO, COO, OCO, CONR3, NR3CO, and where 1 to 5 hydrogen atoms can be replaced by Hal, NR3R4, NO2, OR3, Het, Ar, Cic, or denote Ar, Het or Cic; R8 denotes H, methyl, or a straight or branched chain alkyl group with 2 to 12 carbon atoms, where 1 to 3 CH2 groups may be substituted by a group selected from: O, NR3, S, SO, SO2, CO, COO, OCO, CONR3, NR3CO, and wherein 1 to 5 hydrogen atoms may be replaced by Hal, NR3R4 or NO2; R3, R4 each independently denote H or a straight or branched chain alkyl group having 1 to 12 carbon atoms; Hal denotes F, Cl, Br or I; Het denotes a saturated, unsaturated or aromatic ring, whether monocyclic, bicyclic or fused bicyclic, of 3 to 8 members and containing 1 to 4 heteroatoms selected from N, O and S, which may be substituted with 1 to 3 of the following substituents: NR3R4, NH2, N(CH3)2, phenyl, 2-,3-, or 4-hydroxy or methoxyphenyl, alkyl, CF3, alkoxy(Oalkyl), hydroxyalkylene, alkoxyalkylene, COOH, COOalkyl, CONHalkyl, CONH2, CON(CH3 )2, NHCOalkyl, NHalkyl, CO-N-morpholinyl, CON(CH3)CH2CH2N(CH3)2, CO-1-piperidinyl, CO-4-hydroxy-1-piperidinyl, CO-1-piperazinyl, CO-4-methyl - 1-piperazinyl, CH2-N-morpholinyl, CH2N(H)COCH3, CH2N(CH3)COCH3, Hal and OR3; Ar denotes a 6-membered aromatic carbocyclic ring or bicyclic fused or unfused aromatic ring system, which may be optionally substituted by 1 to 3 substituents independently selected from NR3R4, NH2, N(CH3)2, phenyl , 2-,3- or 4-hydroxy or methoxyphenyl, alkyl, CF3, alkoxy (Oalkyl), hydroxyalkylene, alkoxyalkylene, COOH, COOalkyl, CONHalkyl, CONH2, CON(CH3)2, NHCOalkyl, NHalkyl, CO-N-morpholinyl, CON(CH3)CH2CH2N(CH3)2, CO-1-piperidinyl, CO-4-hydroxy-1-piperidinyl, CO-1-piperazinyl, CO-4-methyl- 1-piperazinyl, CH2-N-morpholinyl, CH2N( H)COCH3, CH2N(CH3)COCH3, OR3 and Hal; Cic denotes a saturated or unsaturated carbocyclic ring with 3 to 8 carbon atoms, which may optionally be substituted with 1 to 3 substituents independently selected from NR3R4, NH2, N(CH3)2, phenyl, 2, 3 or 4-hydroxy or methoxyphenyl, alkyl, CF3, alkoxy(Oalkyl), hydroxyalkylene, alkoxyalkylene, COOH, COOalkyl, CONalkyl, CONH2, CON(CH3)2, NHCOalkyl, NHalkyl, CO-N-morpholinyl, CON(CH3)CH2CH2N(CH3 )2, CO-1-piperidinyl, CO-4-hydroxy-1-piperidinyl, CO-1-piperazinyl, CO-4-methyl-1-piperazinyl, CH2-N-morpholinyl, CH2N(H)COCH3, CH2N(CH3 )COCH3, Hal and OH, as well as solid forms thereof. |
| priorityDate | 2016-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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