http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2878102-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_431309bc8dab94a0ee0e2aa5aeacd48d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D223-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D223-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D223-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-352 |
| filingDate | 2017-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6fcb84690c4c5ff94ece48a5493baf1b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3fdde1fa9aebac70e962f91cd766a01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d064e1f62ac0666a122410a41b323272 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8708f7f006b479e0a65d5cfcd2b1eba5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d1e5e6fb330509f1faf74ea35575d2a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_efcb05e46e3c89a4b161e7bfe320cafa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c415739d01cb34e4d2f68885b204ef7f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8df887bfbfb11f4b6b0a0c0257640863 |
| publicationDate | 2021-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2878102-T3 |
| titleOfInvention | NRF2 activator |
| abstract | A compound represented by Formula I: **(See formula)** or a pharmaceutically acceptable salt thereof, wherein R1 is -CN, -C(O)Ra, CH3S(O)2- or substituted C1-8 alkyl with one or more fluorine atoms; Ra is H, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, a 3 to 12 membered carbocyclyl, a 3 to 12 membered heterocyclyl, -OR11, -SR14, -N(R12)2, -NR13OR13 , -NR13S(O)2R13, -NR13C(O)R13, -N(R13)N(R13)2, -N(R13)C(O)OR13 or -N(R13)C(O)N(R13) 2, wherein each of C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, 3 to 12 membered carbocyclyl, and 3 to 12 membered heterocyclyl is optionally substituted with one or more R21; R2 is H, halo, -NO2, -CN, -N3, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, a 3 to 12 membered carbocyclyl, a 3 to 12 membered heterocyclyl, -C(O )R13, -C(S)R13, -C(O)OR13, -C(S)SR13, -C(O)SR13, -C(S)OR13, -SC(O)R13, -OC(S) R13, -SC(S)R13, -C(O)N(R13)2, -OR11, -SR14, -N(R12)2, -N(R13)OR13, -N(R13)S(O)2R13 , -N(R13)C(O)R13, - N(R13)N(R13)2, -N(R13)C(O)OR13, -N(R13)C(O)N(R13)2, - S(O)2R13, -S(O)R13, -S(O)N(R13)2, -S(O)2N(R13)2, -N+(R13)3, -S+(R13)2 or - Si(R13)3, wherein each of C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, 3 to 12 membered carbocyclyl, and 3 to 12 membered heterocyclyl is optionally substituted with one or more R21; R3a is H, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, a 3 to 12 membered carbocyclyl, a 3 to 12 membered heterocyclyl, -C(O)R13, -C(O)OR13, - C(O)N(R13)2, -OR11, -N(R12)2, -N(R13)OR13, -N(R13)S(O)2R13, -N(R13)C(O)R13, - N(R13)N(R13)2, -N(R13)C(O)OR13, -N(R13)C(O)N(R13)2, -S(O)R13, -S(O)N( R13)2 or -S(O)2N(R13)2, wherein each of C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, 3-12 membered carbocyclyl and 3-12 membered heterocyclyl is substituted optionally with one or more R21; and R3b is C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, a 3 to 12 membered carbocyclyl, a 3 to 12 membered heterocyclyl, -C(O)R13, -C(O)OR13, -C (O)N(R13)2, -OR11, -N(R12)2, -N(R13)OR13, -N(R13)S(O)2R13, -N(R13)C(O)R13, -N (R13)N(R13)2, -N(R13)C(O)OR13, -N(R13)C(O)N(R13)2, -S(O)R13, -S(O)N(R13 )2 or -S(O)2N(R13)2, wherein each of C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, 3-12 membered carbocyclyl and 3-12 membered heterocyclyl is optionally substituted with one or more R21; or R3a and R3b are taken together and are C2-12 alkylene, C2-12 alkenylene, or C2-12 alkynylene; wherein each of C2-12 alkylene, C2-12 alkenylene, C2-12 alkynylene and 3-6 membered carbocyclyl is optionally substituted with one or more R21; R4 is H, halo, -NO2, -CN, -N3, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, a 3 to 12 membered carbocyclyl, a 3 to 12 membered heterocyclyl, -C(O )R13, -C(S)R13, -C(O)OR13, -C(S)SR13, -C(O)SR13, -C(S)OR13, -SC(O)R13, -OC(S) R13, -SC(S)R13, -C(O)N(R13)2, -OR11, -SR14, -N(R12)2, -N(R13)OR13, -N(R13)S(O)2R13 , -N(R13)C(O)R13, - N(R13)N(R13)2, -N(R13)C(O)OR13, -N(R13)C(O)N(R13)2, - S(O)2R13, -S(O)R13, -S(O)N(R13)2, -S(O)2N(R13)2, -N+(R13)3, -S+(R13)2 or - Si(R13)3, wherein each of C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, 3 to 12 membered carbocyclyl, and 3 to 12 membered heterocyclyl is optionally substituted with one or more R21; " " is a single bond or a double bond, where when " is absent; and when " " is a single bond, then " is a double bond, then R5 is R5 is H, halo, -NO2, -CN, - N3, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, a 3 to 12 membered carbocyclyl, a 3 to 12 membered heterocyclyl, -C(O)R13, -C(S)R13, -C( O)OR13, -C(S)SR13, -C(O)SR13, -C(S)OR13, -SC(O)R13, -OC(S)R13, -SC(S)R13, -C(O )N(R13)2, -OR11, -SR14, -N(R12)2, -N(R13)OR13, -N(R13)S(O)2R13, -N(R13)C(O)R13, - 0 N(R13)N(R13)2, -N(R13)C(O)OR13, -N(R13)C(O)N(R13)2, -S(O)2R13, -S(O)R13 , -S(O)N(R13)2, -S(O)2N(R13)2, -N+(R13)3, -S+(R13)2, or -Si(R13)3, where each of alkyl C1-12, C2-12 alkenyl, C2-12 alkynyl, 3-12 membered carbocyclyl and 3-12 membered heterocyclyl is optionally substituted with one or more R21; or R5 and R3b are taken together with the carbons to which they are each attached to form a 3-6 membered carbocyclyl, wherein the 3-6 membered carbocyclyl is optionally substituted with one or more R21; R6, at each occurrence, is independently halo, -NO2, -CN, -N3, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, a 3-12 membered carbocyclyl, a 3-12 membered heterocyclyl, -C(O)R13, -C(S)R13, -C(O)OR13, -C(S)SR13, -C(O)SR13, -C(S)OR13, -SC(O)R13, - OC(S)R13, -SC(S)R13, -C(O)N(R13)2, -OR11, -SR14, -N(R12)2, -N(R13)OR13, -N(R13)S (O)2R13, -N(R13)C(O)R13, -N(R13)N(R13)2, -N(R13)C(O)OR13, -N(R13)C(O)N(R13 )2, -S(O)2R13, -S(O)R13, -S(O)N(R13)2, -S(O)2N(R13)2, -N+(R13)3, -S+(R13 )2 or -Si(R13)3; or two R6 attached to the same ring carbon to form an oxo, =NR14 or C1-12 alkylidene, where each of C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, 3- to 12-membered carbocyclyl, heterocyclyl from 3 to 12 members and C1-12 alkylidene is optionally substituted with one or more R21; X is NRb or O; Rb is H, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, a 3 to 12 membered carbocyclyl, a 3 to 12 membered heterocyclyl, -C(O)Rc, -C(O)ORc, - C(O)NRcRc, -S(O)2Rc, -S(O)2ORc or -S(O)2NRcRc, where each of C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, carbocyclyl of 3 to 12 membered and 3 to 12 membered heterocyclyl is optionally substituted with one or more R21; Rc, at each occurrence, is independently selected from H, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, a 3 to 12 membered carbocyclyl, and a 3 to 12 membered heterocyclyl, where each of C1 alkyl -12, C2-12 alkenyl, C2-12 alkynyl, 3 to 12 membered carbocyclyl and 3 to 12 membered heterocyclyl is optionally substituted with one or more R21; R11, at each occurrence, is independently selected from H, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, 3-12 membered carbocyclyl, 3-12 membered heterocyclyl, C1-12 acyl, and -Si (R13)3, wherein each of C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, 3-12 membered carbocyclyl, 3-12 membered heterocyclyl, and C1-12 acyl is optionally substituted with one or more R21; R12, at each occurrence, is independently selected from H, C1-12 alkyl, C1-12 alkoxy, C2-12 alkenyl, C2-12 alkynyl, 3-12 membered carbocyclyl, 3-12 membered heterocyclyl, and -Si (R13)3, wherein each of C1-12 alkyl, C1-12 alkoxy, C2-12 alkenyl, C2-12 alkynyl, 3 to 12 membered carbocyclyl, and 3 to 12 membered heterocyclyl is optionally substituted with one or more R21; R13, at each occurrence, is independently selected from H, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, a 3 to 12 membered carbocyclyl, and a 3 to 12 membered heterocyclyl, wherein each of C1 alkyl -12, C2-12 alkenyl, C2-12 alkynyl, 3 to 12 membered carbocyclyl, and 3 to 12 membered heterocyclyl is optionally substituted with one or more R21; R14, at each occurrence, is independently selected from H, C1-alkyl 12, C2-12 alkenyl, C2-12 alkynyl, a 3 to 12 membered carbocyclyl, a 3 to 12 membered heterocyclyl, and C1-12 acyl, wherein each of C1-12 alkyl, C2-12 alkenyl, C2 alkynyl -12, 3-12 membered carbocyclyl, 3-12 membered heterocyclyl, and C1-12 acyl is optionally substituted with one or more R21; R21, at each occurrence, is independently selected from halo, -OH, -S(O)2R16, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C1-12 alkoxy, a 3- to 12-membered carbocyclyl, and a 3-12 membered heterocyclyl, wherein each of C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C1-12 alkoxy, 3-12 membered carbocyclyl and 3-12 membered heterocyclyl is optionally substituted with 1 to 3 groups selected from halo, -OH, C1-4 alkyl and C1-4 alkoxy; R16, at each occurrence, is independently selected from H or C1-12 alkyl; n is 0 or an integer from 1 to 8; p is 0, 1 or 2; and q is 1, 2, or 3, provided that the sum of p and q is neither 4 nor 5. |
| priorityDate | 2016-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 1230.