abstract |
A compound of formula (I): ** (See formula) ** wherein: R1 and R2 are independently hydrogen, alkyl, alkoxy, haloalkyl or halo; X is -O-; Ar is phenyl optionally substituted with one, two, or three substituents independently selected from alkyl, halo, haloalkyl, alkoxy, and hydroxy; A is -CR3-, where R3 is hydrogen, alkyl, cyclopropyl, halo, haloalkyl, haloalkoxy, alkoxy, or cyano; Y is a bond or alkylene; ring Z is heterocycloamino optionally substituted with one or two substituents independently selected from alkyl, hydroxy, alkoxy, and fluoro; R5 is a group of formula (i) or (iv): ** (See formula) ** or ** (See formula) ** where: Ra is hydrogen or fluorine; each Rb independently is hydrogen or alkyl; and Rc is hydrogen; and / or a pharmaceutically acceptable salt thereof. |