| abstract |
A compound according to formula I: **(See formula)** in which: R1 is selected from: aryl, aryl substituted from 1 to 4 times with Ra, heteroaryl, heteroaryl substituted from 1 to 4 times with Ra, bicycloheteroaryl, and bicycloheteroaryl substituted 1 to 4 times with Ra; R2 is selected from: aryl, aryl substituted 1 to 4 times with Rb, heteroaryl, heteroaryl substituted 1 to 4 times with Rb, bicycloheteroaryl, and bicycloheteroaryl substituted 1 to 4 times with Rb, and Y1 is selected from: C1 alkyl -6, and C1-6 alkyl substituted with 1 to 9 substituents independently selected from: fluorine, chlorine, bromine, iodine, OC1-6 alkyl, OC1-6 alkyl substituted with 1 to 6 substituents independently selected from: fluorine, oxo , -OH, -COOH, -NH2 and -CN, mercapto, -S(O)H, -S(O)2H, oxo, hydroxy, amino, -NHRx11, where Rx11 is selected from C1-6 alkyl and C1 alkyl -6 substituted with 1 to 6 substituents independently selected from: fluorine, oxo, -OH, -COOH, -NH2, -CN, OC1-5alkyl, OC1-5alkyl substituted 1 to 6 times with fluoro and -NH2, -NRx12Rx13, where Rx12 and Rx13 are each independently selected from C1-6 alkyl and C1-6 alkyl substituted with 1 to 6 substituents independently selected from: fluorine, oxo, -OH, -COOH, -NH2, and -CN, -C(O)OH, -C(O)NH2, aryl, -Oaryl, heteroaryl, -Oheteroaryl, -S(O)2NH2, -NHS (O)2H, nitro, and cyano, or Y1 is taken together with the adjacent -OH to form a heterocyclic ring selected from: morpholinyl, -CH3-substituted morpholinyl, and oxazolidin-2-one; each Ra is independently selected from: fluorine, chlorine, bromine, iodine, -OH, C1-6 alkyl, C1-6 alkyl substituted with 1 to 5 substituents independently selected from: fluorine, chlorine, bromine, iodine, C1-4 alkyl, - OH, C1-4 alkyl, phenyl, oxo, -COOH, -NO2, -NH2 and -CN, cyano, OC1-6 alkyl, OC1-6 alkyl substituted with 1 to 5 substituents independently selected from: fluorine, chlorine, bromine , iodo, C1-4 alkyl, -OH, C1-4 alkyl, phenyl, oxo, -COOH, -NO2, -NH2 and -CN, -Ophenyl, -C(O)O C1-6 alkyl, -C(O )OC1-6 alkyl substituted from 1 to 5 times with fluorine, and -Ocycloalkyl; and each Rb is independently selected from: fluorine, chlorine, bromine, iodine, -OH, C1-6 alkyl, C1-6 alkyl substituted with between 1 and 5 substituents independently selected from: fluorine, chlorine, bromine, iodine, C1-alkyl 4, -OH, C1-4 alkyl, phenyl, oxo, -COOH, -NO2, -NH2 and -CN, cyano, C1-6 alkyl, C1-6 alkyl substituted with between 1 and 5 substituents independently selected from: fluorine, chlorine, bromine, iodine, C1-4 alkyl, -OH, C1-4 alkyl, phenyl, oxo, -COOH, -NO2, -NH2 and -CN, -Ocycloalkyl, phenyl, -C≡C-Si(CH3)3 , and -C≡C-cycloalkyl; or a pharmaceutically acceptable salt thereof. |