| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06T2207-10056
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06T2207-20036
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06T2207-10064
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06T2207-30096
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06T2207-30024 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06V20-698
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6456
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6428
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57484
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06T7-155
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5091
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06T7-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06T7-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06T7-0012 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06T7-136
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06T7-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06T7-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06T7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06T7-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06K9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06T7-174
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-533
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-487
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-483
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06T7-155 |
| filingDate |
2016-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2021-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f52b2dd64ac06a1a017167844440903
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b512557b5759d41688bd28e7de38ab77 |
| publicationDate |
2021-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
ES-2877178-T3 |
| titleOfInvention |
IT processes after an improved version of AQUA |
| abstract |
System for determining a score representative of the proximity between at least one pair of cells in a tumor tissue sample, system comprising: a programmable controller (200) programmed to: receive image data from an imaging device (100) , separating the image data into unmixed image data and providing the data through a plurality of data channels; where raw image data from a first data channel describes fluorescence signals attributable to a cell nucleus, raw data from a second data channel describes fluorescence signals attributable to tumor tissue, raw data from a third channel of data describes fluorescence signals attributable to a first biomarker, and raw image data from a fourth data channel describes fluorescence signals attributable to a second biomarker; receiving image data from the first data channel and generating a representative image of all nuclei in a field of view and dilating the image to generate a mask of cells; receiving image data from the second data channel and generating a mask of the entire tumor area in the field of view; receiving image data from the third data channel and generating a first biomarker mask of all cells in the field of view expressing the first biomarker; receiving image data from the fourth data channel and generating a second biomarker mask of all cells in the field of view expressing the second biomarker; combining the cell mask and tumor area mask to generate at least one non-tumor cell mask and one tumor cell mask; dilating the first biomarker mask by a margin sufficient to encompass proximally located cells expressing the second biomarker to generate a dilated first biomarker mask; combining the dilated first biomarker mask and the second biomarker mask to generate an interaction mask; calculating a spatial proximity score based on the area of the interaction mask and the area of at least one of the non-tumor cell mask, the tumor cell mask, and the cell mask. |
| priorityDate |
2015-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |