| abstract |
A composition comprising: (a) single-stranded RNA; and (b) polyethyleneimine, in which the single-stranded RNA and polyethyleneimine are present in polyplex particles and in which the molar ratio of the number of nitrogen atoms (N) in the polyethyleneimine to the number of phosphorus atoms (P ) in single-stranded RNA (N:P Ratio) is 2.0 to 15.0; for use as a pharmaceutical composition and wherein the use comprises administering the composition to muscle cells or muscle tissue, preferably by intramuscular injection into muscle tissue. |