http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2876293-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4b91f81d741def5fb07a38abbbfa56ed http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9832c7a752d860feaa5ed166f88bf377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_012a4af3dc4ad350c812db1b2033023a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-436 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2018-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c650140fe90d506fbcb4e379b12afdc7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9602d0f4e2dace56e16f457b94715819 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4f74c9cf18c2c7bd1169237cb99949d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b009f36f94c75c06e95f8063a1a31959 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69b5de27a380b4f416176c62380abaec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f59aaafc00d8d9efcf18a6f9eedc60e |
| publicationDate | 2021-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2876293-T3 |
| titleOfInvention | Cyclic compound similar to coumarin as a MEK inhibitor and its use |
| abstract | A compound represented by formula (I), a pharmaceutically acceptable salt thereof, or a tautomer thereof: **(See formula)** wherein, n is selected from 0, 1 or 2; r is selected from 0, 1, 2 or 3; m is selected from 0 or 1; when m is 0, then **(See formula)** is H; ring A is selected from phenyl or 5-6 membered heteroaryl; L is selected from a single bond, -S(=O)-, -S(=O)2-, -C(=O)-, -NH-, -NH-C(=O)-, -NH- C(=O)-O-, -NH-S(=O)2-, -NH-S(=O)- and -NH-C(=O)-NH-, where the -NH-, -NH-C(=O)-, -NH-C(=O)-O-, -NH-S(=O)2-, -NH-S(=O)- and -NH-C(=O )-NH- are each optionally substituted with 1, 2 or 3 R; R1 is selected from H, NH2, C1-6 alkyl, 3-6 membered heterocycloalkyl, C3-6 cycloalkyl, and C1-3 heteroalkyl, wherein NH2, C1-6 alkyl, 3-6 membered heterocycloalkyl, C3 cycloalkyl -6 and C1-3 heteroalkyl are each optionally substituted with 1, 2 or 3 R; R2 is selected from H, C1-6 alkyl, C1-6 heteroalkyl, C3-6 cycloalkyl, and 5-6 membered heterocycloalkyl, wherein C1-6 alkyl, C1-6 heteroalkyl, C3-6 cycloalkyl, and 5-membered heterocycloalkyl -6 members are each optionally substituted with 1, 2 or 3 R; R3 is selected from H, F, Cl, Br, I, C1-3 alkyl, C1-3 alkoxy, C1-4 alkynyl, C1-4 alkenyl, and phenyl, wherein C1-3 alkyl, C1-3 alkoxy, C1-4 alkynyl, C1-4 alkenyl and phenyl are each optionally substituted with 1, 2 or 3 R; R4 and R5 are independently selected from H, F, Cl, Br, I, NH2, OH, C1-6 alkyl, and C1-3 alkoxy, wherein C1-6 alkyl and C1-3 alkoxy are each optionally substituted with 1, 2 or 3 R; or R3 and R4 are bonded together to form 5-7 membered cycloalkyl, 5-7 membered heterocycloalkyl, 5-7 membered aryl, or 5-7 membered heteroaryl; R6 and R7 are independently selected from H, F, Cl, Br, I, CH3, Et, CH3-O- and CH3-CH2-O-; R is selected from F, Cl, Br, I, OH, NH2, C1-3 alkyl, and C1-3 heteroalkyl, wherein NH2, C1-3 alkyl, and C1-3 heteroalkyl are each optionally substituted with 1, 2 or 3 R'; R' is selected from F, Cl, Br, I, NH2 or C1-3 alkyl; each of "hetero" in 5-6 membered heteroaryl, 5-6 membered heterocycloalkyl, 3-6 membered heterocycloalkyl, C1-3 heteroalkyl, 5-7 membered heterocycloalkyl, 5-7 membered heterocycloalkyl, aryl 5-7 membered and 5-7 membered heteroaryl is independently selected from -NH-, N, -O-, -S(=O)2-, -S(=O)2-NH-, -NH-S (=O)2-NH-, -C(=O)-NH-, -S(=O)-, -C(=O)-, -S(=O)-NH- and -O-C(=O )-NH-; in any of the above cases, the number of the heteroatom or heteroatomic group is independently selected from 1, 2, 3 or 4. |
| priorityDate | 2017-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 331.