http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2875747-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bc2b03342511abc88f60c63f2acd96d0 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5158 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5156 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-01 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1086 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0011 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70521 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-7051 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90 |
| filingDate | 2017-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_303a97e306d1264cb463195b7efc9eee http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41049eb019791ad6812d47bf133a2ae3 |
| publicationDate | 2021-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2875747-T3 |
| titleOfInvention | Chimeric proteins and immunotherapy methods |
| abstract | A combination of polypeptides for the conditional regulation of an immune cell, comprising the polypeptides: (a) a chimeric transmembrane receptor polypeptide comprising (i) an extracellular region comprising an antigen-binding antigen-interacting domain and ( ii) an intracellular region comprising an immune cell signaling domain; (b) a chimeric adapter polypeptide comprising a receptor-binding residue that binds to the receptor polypeptide when the receptor polypeptide has undergone receptor modification upon binding to antigen; (c) a gene modulator polypeptide (GMP) comprising an actuator residue linked to a cleavage recognition site, wherein, upon release of the GMP, the actuator residue is capable of regulating gene expression and/or activity of a target polynucleotide; and (d) a cleavage residue that cleaves the cleavage recognition site when it is in proximity to the cleavage recognition site to release the GMP actuator residue; wherein, in response to antigen binding, the receptor is modified and the chimeric adapter polypeptide is recruited to the receptor; wherein: (i) the cleavage residue forms a portion of the intracellular region of the receptor polypeptide and GMP forms a portion of the chimeric adapter polypeptide, wherein binding of the chimeric adapter polypeptide to the receptor brings the cleavage residue closer to the recognition site cleavage and wherein the cleavage residue cleaves the cleavage recognition site to release the GMP actuator residue; (ii) the cleavage residue forms a complex with a second adapter polypeptide that binds to the receptor polypeptide that has undergone receptor modification by binding to an antigen and the GMP forms a portion of the chimeric adapter polypeptide, wherein the polypeptide binding chimeric adapter and also of the second adapter polypeptide to the receptor brings the cleavage residue closer to the cleavage recognition site and wherein the cleavage residue cleaves the cleavage recognition site to release the GMP actuator residue; or (iii) the cleavage residue forms a portion of the chimeric adapter polypeptide and the GMP forms a portion of the intracellular region of the receptor polypeptide, wherein binding of the chimeric adapter polypeptide to the receptor brings the cleavage residue closer to the cleavage recognition site and wherein the cleavage residue cleaves the cleavage recognition site to release the GMP actuator residue |
| priorityDate | 2016-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 586.