http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2875329-T3
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0f4246e8fcebf17c365aced017a04c61 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-34 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-08 |
filingDate | 2017-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2021-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa52d190f71802b9eb0e68cf96ea7241 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_178b1a309c3c196b056ccaa3e0b44be1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e83867942e10d9d2a5957205bd0588da http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37f93c376761279eb8ccb5d15f337615 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a86781c204fc485a1b2f26f6857ed959 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ecf2767af16b8ede5d5a777e8009d4c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3aedd463c87304d9d1956679430bbfc7 |
publicationDate | 2021-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | ES-2875329-T3 |
titleOfInvention | Tetrahydroisoquinoline kappa opioid antagonists |
abstract | (3R)-7-Hydroxy-N-[(1S)-2-methyl-1-(piperidin-1-ylmethyl)propyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3R)-7 - Hydroxy-N-[(1S)-1-(hydroxymethyl)-2-methylpropyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3R)-7-Hydroxy-N-[(1S)- 2- Methyl-1-(morpholin-4-ylmethyl)propyl]-1,2,3,4-tetrahydroisoquinolin-3-carboxamide, (3R)-N-[(1S)-1-(Azepan-1-ylmethyl) -2- methylpropyl]-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3R)-7-Hydroxy-N-{(1S)-2-methyl-1-[(4-methylpiperidine - 1-yl)methyl]propyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3R)-N-{(1S)-1-[(Dipropylamino)methyl]-2-methylpropyl}-7 - hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3R)-N-{(1S)-1-[(4,4-Dimethylpiperidin-1-yl)methyl]-2-methylpropyl}- 7- Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3R)-N-{(1S)-1-{[Bis(2-methylpropyl)amino]methyl}-2-methylpropyl]-7 - hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3R)-N-{(1S)-1-[(4,4-Diethylamino)methyl]-2-methylpropyl]-7-hydroxy- 10 1,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3R)-7-Hydroxy-N-{(1S)-2-methyl-1-[(2-methylpiperidin-1-yl)methyl]propyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3R)-7-Hydroxy-N-{(1S)-2-methyl-1-[(4-methoxypiperidin-1-yl)methyl]propyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3R)-7-Hydroxy-N-[(1S)-2-methyl-1-{[4-(trifluoromethyl)piperidin-1- yl]methyl}propyl]-1,2,3,4-tetrahydroisoquinolin-3 -carboxamide, (3R)-N-{(1S)-1-[(3,5-Dimethylpiperidin-1-yl)methyl]-2-methylpropyl}-7-hydroxy-1,2,3,4-tetrahydroisoquinolin-3 -carboxamide, (3S)-7-Hydroxy-N-{(1S)-2-methyl-1-[(4-methylpiperidin-15-1-yl)methyl]propyl}-1,2,3,4-tetrahydroisoquinolin- 3-carboxamide, (3R)-7-Hydroxy-N-{(1R)-2-methyl-1-[(4-methylpiperidin-1- yl)methyl]propyl}-1,2,3,4-tetrahydroisoquinolin- 3-carboxamide, (3S)-7-Hydroxy-N-{(1R)-2-methyl-1-[(4-methylpiperidin-1- yl)methyl]propyl}-1,2,3,4-tetrahydroisoquinolin- 3-carboxamide, (3R)-7-Hydroxy-N-{(1S)-2-methyl-1-[(4-methylpiperizin-1- yl)methyl]propyl}-1,2,3,4-tetrahydroisoquinolin- 3-carboxamide, (3R)-N3-{(1S)-2-methyl-1-[(4-methylpiperidine-1- yl)methyl]propyl}- 1,2,3,4-tetrahydroisoquinolin-3,7-dicarboxamide, (3R)-7-Hydroxy-N-{(1S)-2-methyl-1-[(5-methyl- 3,6-dihydropyridin-1(2H)-20 yl)methyl]propyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3R)-N-{(1S)-1-[(4- Carbamoylpiperidin-1-yl)methyl]-2- methylprolyl}-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3R)-7-Hydroxy-N-{(1S)-2-methyl -1-[(3-methylpiperidin-1- yl)methyl]propyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3R)-N-{(1S)-1-[(4-Ethylpiperidine -1-yl)methyl]-2-methylpropyl}-7- hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3R)-7-hydroxy-N-{(1S)-2-methyl- 1-[(4-methyl-3,6-dihydropyridin-1(2H)- yl)methyl]propyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3R)-N-[(1S) -1-Cyclopropyl-2-(4-methylpiperidin-1-yl)ethyl]-7- 25 hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3R)-7-Fluoro-N-{( 1S)-2-methyl-1-[(4-methylpiperidin-1- yl)methyl]propyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3R)-7-Methoxy-N-{( 1S)-2-methyl-1-[(4-methylpiperidin-1-yl)methyl]propyl}-1,2,3,4-te trahydroisoquinoline-3-carboxamide, (3R)-7-Hydroxy-N-methyl-N-{(1S)-2-methyl-1-[(4-methylpiperidin-1-yl)methyl]propyl}-1,2, 3,4-tetrahydroisoquinoline-3-carboxamide, (3R)-N-{(1S)-1-[(4,5-dimethyl-3,6-dihydropyridin-1(2H)-yl)methyl]-2-methylpropyl }-7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3R)-7-Hydroxy-N-[(1S)-2-methyl-1-30(pyrrolidine-1-ylmethyl)propyl ]-1,2,3,4-tetrahydroisoquinolin-3-carboxamide, (3R)-N-[(1S)-1-(3,6-dihydropyridin-1(2H)-ylmethyl)-2-methylpropyl]-7 -hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3R)-7-Hydroxy-N-{(1S)-2-methyl-1-[(2-oxopiperidin-1-yl)methyl] propyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3R)-7-Hydroxy-N-(2-piperidine-1-ylethyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide , (3R)-N-[(1R)-1-(Cyclohexylmethyl)-2-methylpropyl]-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3R)-N3-[(1R )-1-(Cyclohexylmethyl)-2-methylpropyl]-1,2,3,4-tetrahydroisoquinoline-3,7-dicarboxamide, (3R)-N-{(1S)-1-[(4-Cyanopiperidine-1- yl)methyl]-2-methylprolyl}-7-hydro xi-1,2,3,4-tetrahydroisoquinoline-3- carboxamide, (3R)-N-[(1R)-1-(Cyclopentylmethyl)-2-methylpropyl]-7-hydroxy-1,2,3,4- tetrahydroisoquinoline-3-carboxamide, (3R)-N-[(1R)-1-(Cycloheptylmethyl)-2-methylpropyl]-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3R)- N-[(1S)-1- (Cyclohexylmethyl)-2-methylpropyl]-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3R)-N-[(1R)-1-( Cyclohexylmethyl)- 2-methylpropyl]-7-methoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3R)-N-[(1R)-1-(Cyclohexylmethyl)-2-methylpropyl]- 40 1 ,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3S)-N-[(1S)-1-(Cyclohexylmethyl)-2-methylpropyl]-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3 -carboxamide, (3S)-N-[(1R)-1-(Cyclohexylmethyl)-2-methylpropyl]-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3R)-N-[ (1R)-1-(Cyclohexylmethyl)-2-methylpropyl]-7-fluoro-1,2,3,4- tetrahydroisoquinoline-3-carboxamide, (3R)-N-[(1R)-1-(Cyclohexylmethyl)- 2-methylpropyl]-7-hydroxy-2-methyl-1,2,3,4- tetrahydroisoquinoline-3-carboxamide, (3R)-N-[(1S)-1-{ [(3S,4R)-3,4-Dimethylpiperidin-1-yl]methyl}-2-methylpropyl]-7-hydroxy- 45 1,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3R)-N- [(1S)-1-{[(3S,4R)-3,4-Dimethylpiperidin-1-yl]methyl}-2-methylpropyl]-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide , (3R)-N-[(1S)-1-(7-Azabicyclo[2.2.1]hept-7-ylmethyl)-2-methylpropyl]-7-hydroxy-1,2,3,4-tetrahydroisoquinolin-3 -carboxamide, (3R)-N-[(1R)-2-Cyclohexyl-1-cyclopropylethyl]-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3R)-N-[(1R )-2-Cyclohexyl-1-phenylethyl]-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3- carboxamide, (3R)-3-[(Methyl{(1S)-2-methyl-1-[ (4-methylpiperidin-1-yl)methyl]propyl}amino)methyl]-1,2,3,4-tetrahydroisoquinolin-0 7-ol, (3R)-N-{[(1S)-1-[4, 4-Difluoropiperidin-1-yl]methyl]-2-methylpropyl}-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3- carboxamide, (3R)-N-(2-Cyclohexylethyl)-7-hydroxy- 1,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3R)-7-Hydroxy-N-(2-phenylethyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3R)-3- [({(1S)-2-Methyl-1-[(4-methylpipe ridin-1- yl)methyl]propyl}amino)methyl]-1,2,3,4-tetrahydroisoquinolin-7-ol, (3R)-N-[(1S)-1-{[4-(Dimethylamino)piperidine -1-yl]methyl}-2- methylpropyl]-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, (3R)-N-[(1S)-1-{[4-(Difluoromethyl )piperidin-1- 5 yl]methyl}-2-methylpropyl]-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, methylpropyl]-7-hydroxy-3-methyl-1,2,3 ,4-tetrahydroisoquinoline-3-carboxamide, (3R)-N-[(1R)-1-(Cyclopentylmethyl)-2- (3R)-N3-[(1R)-1-(Cyclopentylmethyl)-2- methylpropyl]- 1,2,3,4-tetrahydroisoquinoline-3,7-dicarboxamide, (3R)-N-[(1R)-1-(Cyclobutylmethyl)-2-methylpropyl]-7-hydroxy-1,2,3,4- tetrahydroisoquinoline-3-carboxamide, 6-Hydroxy-N-{(1S)-2-methyl-1-[(4-methylpiperidin-1-yl)methyl]propyl}naphthalene-2-carboxamide, (3R)-N-[ (1R)-2-Cyclopentyl-1-cyclopropylethyl]-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, 6- 60 Hydroxy-N-{(1S)-2-methyl-1-[ (4-methylpiperidin-1-yl)methyl]propyl}-1,2,3,4-tetrahydronaphthalene-2-carboxamide or (3R)-7-Hydroxy-N-{(1R)-2-methyl-1-[ (4-methylcyclohe xyl)methyl]propyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide or a salt thereof. |
priorityDate | 2016-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
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