http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2873895-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12a9e9ce63eb0bbf3658453fb50a6d9b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4162 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-438 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-22 |
| filingDate | 2016-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50366cd58011bce2d6a5f615cd849f07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_672c4faffce2de3ca04265364e38a87c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1bd7adedbbc6c6facd79fa3637d02fa9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14d445f4b12dda783b31958c78c5d6db http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a31fbf9147f0aeb7f59fc3c73755112d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f30c6d974b4b602ad938d4acdc7c635d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6437a48ce6570ca59a8b3bac0bdc9260 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de8a2b105ddd9d3f22c209c132805a4c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_efaaffc2280e0e52e838cd8afc7a6ae5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d7be76cc778f8059e3d06e747fe29df |
| publicationDate | 2021-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2873895-T3 |
| titleOfInvention | Spiro [3H-indole-3,2-pyrrolidin] -2 (1H) -one compounds and derivatives as inhibitors of MDM2-p53 |
| abstract | A compound of formula (I) ** (See formula) ** in which - R1 is a group, optionally substituted with one or more, identical or different Rb1 and / or Rc1, selected from C1-6 alkyl, C2-alkenyl- 6, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, C4-7 cycloalkenyl, C6-10 aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl; each Rb1 is independently selected from -ORc1, -NRc1Rc1, halogen, -CN, -C (O) Rc1, -C (O) ORc1, -C (O) NRc1Rc1, -S (O) 2Rc1, -S (O) 2NRc1Rc1, -NHC (O) Rc1, -N (C1-4 alkyl) C (O) Rc1 and the bivalent substituent = O, while = O can only be a substituent in non-aromatic ring systems; each Rc1 independently of one another represents hydrogen or a group, optionally substituted with one or more, identical or different Rd1 and / or Re1, selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, C4-7 cycloalkenyl, C6-10 aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl; each Rd1 is independently selected from -ORe1, -NRe1Re1, halogen, -CN, -C (O) Re1, -C (O) ORe1, -C (O) NRe1Re1, -S (O) 2Re1, -S (O) 2NRe1Re1, -NHC (O) Re1, -N (C1-4 alkyl) C (O) Re1 and the bivalent substituent = O, while = O can only be a substituent on non-aromatic ring systems; each Re1 independently of one another represents hydrogen or a group, optionally substituted with one or more, identical or different Rf1 and / or R91, selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, C4-7 cycloalkenyl, C6-10 aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl; each Rf1 is independently selected from -ORg1, -NRg1Rg1, halogen, -CN, -C (O) Rg1, -C (O) ORg1, -C (O) NRg1Rg1, -S (O) 2Rg1, -S (O) 2NRg1Rg1, -NHC (O) Rg1, -N (C1-4 alkyl) C (O) Rg1 and the bivalent substituent = O, while = O can only be a substituent on non-aromatic ring systems; Each Rg1 is independently selected from hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, C4-7 cycloalkenyl, C6-10 aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl; - one of R2 and R3 is hydrogen and the other is selected from 5-6 membered phenyl and heteroaryl, wherein said 5-6 membered phenyl and heteroaryl is optionally substituted with one or more, identical or different Rb2 and / or Rc2; each Rb2 is independently selected from -ORc2, -NRc2Rc2, halogen, -CN, -C (O) Rc2, -C (O) ORc2, -C (O) NRc2Rc2, -S (O) 2Rc2, -S (O) 2NRc2Rc2, -NHC (O) Rc2 and -N (C1-4 alkyl) C (O) Rc2; each Rc2 independently of one another represents hydrogen or a group selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-6 cycloalkyl, C4-6 cycloalkenyl, phenyl, 5-6 heteroaryl membered and 3-7 membered heterocyclyl; - A is selected from phenyl and 5-6 membered heteroaryl if F is carbon or A is nitrogen-containing heteroaryl, 5-6 membered if F is nitrogen; each R4 is independently selected from Ra4 and Rb4; each Ra4 independently of one another is a group, optionally substituted with one or more, identical or different Rb4 and / or Rc4, selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3 cycloalkyl -7, C4-7 cycloalkenyl, C6-10 aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl; each Rb4 is independently selected from -ORc4, -NRc4Rc4, halogen, -CN, -C (O) Rc4, -C (O) ORc4, -C (O) NRc4Rc4, -C (O) NRg4ORc4, -S (O) 2Rc4, -S (O) 2NRc4Rc4, -NHSO2Rc4, -N (C1-4 alkyl) SO2Rc4, -NHC (O) Rc4 and -N (C1-4 alkyl) C (O) Rc4; each Rc4 independently of one another represents hydrogen or a group, optionally substituted with one or more, identical or different Rd4 and / or Re4, selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, C4-7 cycloalkenyl, C6-10 aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl; each Rd4 is independently selected from -ORe4, -NRe4Re4, halogen, -CN, -C (O) Re4, -C (O) ORe4, -C (O) NRe4Re4, -C (O) NRg4ORe4, -S (O) 2Re4, -S (O) 2NRe4Re4, -NHC (O) Re4 and -N (C1-4 alkyl) C (O) Re4; each Re4 independently of one another represents hydrogen or a group, optionally substituted with one or more, identical or different Rf4 and / or Rg4, selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, C4-7 cycloalkenyl, C6-10 aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl; each Rf4 is independently selected from -ORg4, -NRg4Rg4, halogen, -CN, -C (O) Rg4, -C (O) ORg4, -C (O) NRg4Rg4, -C (O) NRg4ORg4, -S (O) 2Rg4, -S (O) 2NRg4Rg4, -NHC (O) Rg4 and -N (C1-4 alkyl) C (O) Rg4; Each Rg4 is independently selected from hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-7 cycloalkyl, C4-7 cycloalkenyl, C6-10 aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl; r represents the number 0, 1, 2 or 3; - n represents the number 1 or 2; - each R7 is independently selected from halogen, C1-4 alkyl, -CN, C1-4 haloalkyl, -OC 1-4alkyl and -OhaloC 1-4alkyl; q represents the number 0, 1, 2 or 3; - W, X and Y are -CH = with the proviso that the hydrogen in each -CH = can be replaced by a substituent R7 if present; - V is oxygen or sulfur; - D is nitrogen, E is carbon and F is carbon; or D is a carbon atom, E is nitrogen, and F is carbon; or D is a carbon atom, E is carbon, and F is nitrogen; or a salt of it. |
| priorityDate | 2015-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 1186.