| abstract |
Replication-defective chimpanzee adenoviral vector (ChAd) comprising an adenoviral genome comprising a nucleotide sequence encoding a peptide as set forth in SEQ ID NO:57 or 96 and a transgene encoding at least one immunogen, wherein said vector is modified in that at least one adenoviral gene selected from the group consisting of adenoviral E1, E2, E3 and E4 is functionally deleted. |